Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE131984_Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | NA | Malignant cells | -0.346952 | 5.47e-09 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | post | B cells | 0.315794 | 3.14e-04 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | post | NK cells | 0.386597 | 0.00e+00 |
GSE164551 | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Immunotherapy | CAR-T | NA | CD4+ T cells | -0.279479 | 3.41e-02 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD8+ T cells | -0.321541 | 0.00e+00 |
GSE189460 | patients | Bone marrow aspirate | Multiple myeloma | Multiple myeloma (MM) | Targeted therapy | bortezomib + melphalan + prednisolone | pre | CD8+ T cells | -0.266851 | 1.33e-11 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | post | CD8+ T cells | -0.343734 | 0.00e+00 |
GSE139386 | H3122 cell line | Cell line | Lung cancer | EML4-ALK fusion-positive non-small cell lung cancer (NSCLC) | Targeted therapy | ceritinib | NA | Malignant cells | -0.39526 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | NK cells | -0.627218 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD4+ T cells | -0.501992 | 0.00e+00 |
GSE131984_JQ1Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + paclitaxel | NA | Malignant cells | -0.279387 | 1.44e-08 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | -0.428169 | 1.59e-21 |
GSE104987 | MCF7 cell line | Cell line | Breast cancer | ER+ breast cancer | Targeted therapy | KDM5-C70 | NA | Malignant cells | -0.256172 | 1.01e-08 |
GSE131984_Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | palbociclib | NA | Malignant cells | -0.351129 | 7.76e-11 |
GSE161801_IMiD | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | pomalidomide + dexamethasone OR lenalidomide + dexamethasone | pre | NK cells | -0.268512 | 3.92e-16 |
Gene symbol | motif | TF_highConf |
IDI1 | homer__TWVGGTCCGC_HINFP | HINFP (directAnnotation). |
IDI1 | metacluster_172.23 | ZBTB32; ZBTB32 (directAnnotation). |
IDI1 | metacluster_111.6 | GMEB1; GMEB2 (directAnnotation). |
IDI1 | metacluster_174.2 | CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology). |
IDI1 | metacluster_191.2 | ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology). |
IDI1 | taipale_tf_pairs__ETS2_RCCGGAAGTG_HT | ETS2 (directAnnotation). |
IDI1 | dbtfbs__E2F8_representative_N1 | E2F8 (directAnnotation). |
IDI1 | jaspar__MA1483.2 | ELF2 (directAnnotation). |
IDI1 | metacluster_15.3 | E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology). |
IDI1 | transfac_pro__M04826 | EP300 (directAnnotation). |
IDI1 | metacluster_191.3 | EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology). |
IDI1 | taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP | ETV5; HOXA2 (directAnnotation). |
IDI1 | hdpi__ETV4 | ETV4 (directAnnotation). |
IDI1 | jaspar__MA1122.1 | TFDP1 (directAnnotation). |
IDI1 | metacluster_166.4 | BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology). |
IDI1 | swissregulon__hs__ELF2 | ELF2 (directAnnotation). |
IDI1 | taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT | ELK1; HOXA1 (directAnnotation). |
IDI1 | metacluster_138.2 | ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology). |
IDI1 | transfac_pro__M01251 | E2F1 (directAnnotation). |
IDI1 | jaspar__MA1933.1 | SREBF2 (directAnnotation). |
IDI1 | transfac_pro__M05542 | SNAPC4 (directAnnotation). |
IDI1 | transfac_pro__M06801 | SALL2 (inferredBy_Orthology). |
IDI1 | transfac_pro__M05721 | ZNF235 (directAnnotation). |
IDI1 | transfac_pro__M01010 | HMGA1; HMGA2 (directAnnotation). |
IDI1 | kznf__ZKSCAN2_Imbeault2017_OM_RCADE | ZKSCAN2 (directAnnotation). |
IDI1 | kznf__ZNF613_Imbeault2017_RP_RCADE | ZNF613 (directAnnotation). |
IDI1 | transfac_pro__M06811 | ZNF528 (directAnnotation). |
IDI1 | jaspar__MA1125.1 | ZNF384 (directAnnotation). |
IDI1 | hocomoco__HSFY1_HUMAN.H11MO.0.D | HSFY1; HSFY2 (directAnnotation). |
IDI1 | taipale_tf_pairs__GCM2_DRGX_RTRSGGGNNAATTAN_CAP_repr | DRGX; GCM2 (directAnnotation). |
IDI1 | transfac_pro__M02850 | ELF3 (inferredBy_Orthology). |
IDI1 | tfdimers__MD00076 | HNF1A; HNF1B; PPARG (directAnnotation). |
IDI1 | metacluster_82.7 | BARHL1; ZSCAN29 (directAnnotation). |
IDI1 | taipale_tf_pairs__TEAD4_FIGLA_GGAATKNNCASSTG_CAP_repr | FIGLA; TEAD4 (directAnnotation). |
IDI1 | tfdimers__MD00186 | NFATC3; SPI1 (directAnnotation). |
IDI1 | homer__NAACAGCTGG_Tcf21 | TCF21 (directAnnotation). |
IDI1 | metacluster_130.3 | ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology). |
IDI1 | metacluster_130.2 | ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology). |
IDI1 | taipale_tf_pairs__TEAD4_FIGLA_GGAATKNNCASSTG_CAP | FIGLA; TEAD4 (directAnnotation). |
IDI1 | metacluster_27.12 | ZNF274 (directAnnotation). |
IDI1 | swissregulon__hs__SPI1 | SPI1 (directAnnotation). |
IDI1 | metacluster_155.3 | PLAG1 (directAnnotation). PLAG1 (inferredBy_Orthology). |
IDI1 | transfac_pro__M01660 | GABPA (directAnnotation). |
IDI1 | metacluster_177.7 | ZBTB18; ZBTB18; ZBTB18; ZBTB42 (directAnnotation). |
IDI1 | metacluster_8.3 | BCL11A; RUNX1; RUNX1; RUNX1; RUNX1; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3 (directAnnotation). CBFB; RUNX1; RUNX1; RUNX1; RUNX1; RUNX2; RUNX2; RUNX2; RUNX2; RUNX3; RUNX3; RUNX3 (inferredBy_Orthology). |
IDI1 | flyfactorsurvey__Mad_FlyReg_FBgn0011648 | SMAD9 (inferredBy_Orthology). |
IDI1 | transfac_pro__M04893 | TAF1 (directAnnotation). |
IDI1 | transfac_pro__M01199 | TRIM28 (directAnnotation). |
IDI1 | hdpi__TIMELESS | TIMELESS (directAnnotation). |
IDI1 | idmmpmm__Mad | SMAD9 (inferredBy_Orthology). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |