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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ID4

Summary for ID4

Gene information	Gene symbol	ID4
	Ensembl ID	ENSG00000172201
	Entrez ID	3400
	Gene name	inhibitor of DNA binding 4
	Synonyms	bHLHb27
	Gene type	protein_coding
	UniProtAcc	P47928

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Dataset with differentially expressed gene: ID4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.85317	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.555653	0.00e+00

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Expression of ID4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ID4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ID4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ID4	hsa-miR-7110-3p	99.2563	NM_001546
ID4	hsa-miR-216b-3p	98.5454	NM_001546
ID4	hsa-miR-203a-3p	98.3912	NM_001546
ID4	hsa-miR-1284	98.1157	NM_001546
ID4	hsa-miR-27a-3p	94.9725	NM_001546
ID4	hsa-miR-9985	94.9725	NM_001546
ID4	hsa-miR-27b-3p	94.9725	NM_001546
ID4	hsa-miR-4666a-3p	94.4192	NM_001546
ID4	hsa-miR-3160-3p	94.3817	NM_001546
ID4	hsa-miR-3678-3p	93.9868	NM_001546
ID4	hsa-miR-4709-3p	92.8115	NM_001546
ID4	hsa-miR-5571-5p	92.3297	NM_001546
ID4	hsa-miR-338-5p	91.7268	NM_001546
ID4	hsa-miR-379-3p	91.6942	NM_001546
ID4	hsa-miR-411-3p	91.6942	NM_001546
ID4	hsa-miR-342-3p	90.8934	NM_001546
ID4	hsa-miR-668-3p	90.6019	NM_001546
ID4	hsa-miR-6875-3p	90.5684	NM_001546
ID4	hsa-miR-4659b-3p	88.9127	NM_001546
ID4	hsa-miR-4659a-3p	88.9127	NM_001546
ID4	hsa-miR-153-5p	88.7914	NM_001546
ID4	hsa-miR-543	88.7722	NM_001546
ID4	hsa-miR-4699-5p	88.7317	NM_001546
ID4	hsa-miR-10523-5p	88.5683	NM_001546
ID4	hsa-miR-9-3p	87.7364	NM_001546
ID4	hsa-miR-524-5p	86.7029	NM_001546
ID4	hsa-miR-520d-5p	86.7029	NM_001546
ID4	hsa-miR-4527	86.4052	NM_001546
ID4	hsa-miR-6503-5p	86.3153	NM_001546
ID4	hsa-miR-3168	86.1246	NM_001546
ID4	hsa-miR-3646	85.5565	NM_001546
ID4	hsa-miR-7160-5p	85.1846	NM_001546
ID4	hsa-miR-122b-5p	84.9972	NM_001546
ID4	hsa-miR-98-3p	84.8869	NM_001546
ID4	hsa-let-7f-1-3p	84.8869	NM_001546
ID4	hsa-let-7b-3p	84.8869	NM_001546
ID4	hsa-let-7a-3p	84.8869	NM_001546
ID4	hsa-miR-5011-5p	84.3355	NM_001546
ID4	hsa-miR-3662	84.0151	NM_001546
ID4	hsa-miR-1179	83.9237	NM_001546
ID4	hsa-miR-550b-2-5p	83.2931	NM_001546
ID4	hsa-miR-5699-5p	83.1582	NM_001546
ID4	hsa-miR-345-5p	83.1422	NM_001546
ID4	hsa-miR-9-5p	82.7091	NM_001546
ID4	hsa-miR-3143	82.408	NM_001546
ID4	hsa-miR-100-3p	82.1607	NM_001546
ID4	hsa-miR-513a-5p	82.1083	NM_001546
ID4	hsa-miR-6817-3p	81.2284	NM_001546
ID4	hsa-miR-6892-3p	80.0366	NM_001546

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Motifs and transcription factors (TFs) regulating ID4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ID4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ID4	jaspar__MA1483.2	ELF2 (directAnnotation).
ID4	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ID4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ID4	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ID4	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ID4	jaspar__MA1933.1	SREBF2 (directAnnotation).
ID4	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ID4	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ID4	cisbp__M02645	ETS1 (directAnnotation).
ID4	cisbp__M08198	ELF1 (directAnnotation).
ID4	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ID4	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
ID4	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ID4	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
ID4	transfac_pro__M06331	ZNF343 (directAnnotation).
ID4	jaspar__MA0502.2	NFYB (directAnnotation).
ID4	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ID4	transfac_pro__M04918	EGR1 (directAnnotation).
ID4	metacluster_7.13	ZFX (directAnnotation).
ID4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ID4	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ID4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ID4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ID4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ID4	cisbp__M00249	WT1 (directAnnotation).
ID4	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ID4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ID4	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ID4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ID4	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ID4	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
ID4	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."