Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ID1

Summary for ID1

Gene information	Gene symbol	ID1
	Ensembl ID	ENSG00000125968
	Entrez ID	3397
	Gene name	inhibitor of DNA binding 1
	Synonyms	bHLHb24\|dJ857M17.1.2
	Gene type	protein_coding
	UniProtAcc	P41134

Top

Dataset with differentially expressed gene: ID1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	1.29187	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.344071	3.80e-13
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.276276	5.46e-36
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-0.694318	2.37e-04
GSE150930	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Mucosa-assisted lymphoid tissue (MALT) lymphoma	Immunotherapy	rituximab + cyclophosphamide + fludarabine	NA	Malignant cells	-0.431372	1.93e-23
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.433497	4.98e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	1.09754	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.455868	1.29e-26
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.439697	2.19e-31
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.54799	2.49e-14
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.760408	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	-0.609268	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-1.16067	0.00e+00

Top

Expression of ID1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ID1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ID1	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating ID1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ID1	hsa-miR-338-5p	95.6138	NM_181353
ID1	hsa-miR-4289	94.3447	NM_181353
ID1	hsa-miR-2054	93.5317	NM_181353
ID1	hsa-miR-3613-3p	91.8845	NM_002165
ID1	hsa-miR-4666a-3p	91.3804	NM_181353
ID1	hsa-miR-670-3p	90.0458	NM_002165
ID1	hsa-let-7b-3p	88.481	NM_181353
ID1	hsa-let-7a-3p	88.481	NM_181353
ID1	hsa-miR-98-3p	88.481	NM_181353
ID1	hsa-let-7f-1-3p	88.481	NM_181353
ID1	hsa-miR-4251	86.7158	NM_181353
ID1	hsa-miR-3200-5p	86.2701	NM_181353
ID1	hsa-miR-3191-5p	86.0477	NM_181353
ID1	hsa-miR-195-3p	85.9573	NM_181353
ID1	hsa-miR-16-2-3p	85.9573	NM_181353
ID1	hsa-miR-300	85.5752	NM_181353
ID1	hsa-miR-381-3p	85.5752	NM_181353
ID1	hsa-miR-92b-5p	84.9	NM_181353
ID1	hsa-miR-6764-3p	84.0717	NM_181353
ID1	hsa-miR-1277-5p	81.9634	NM_181353
ID1	hsa-miR-6824-3p	81.9366	NM_181353
ID1	hsa-miR-3184-3p	80.9591	NM_181353

Page: 1

Top

Motifs and transcription factors (TFs) regulating ID1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ID1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ID1	transfac_pro__M06692	PRDM10 (directAnnotation).
ID1	transfac_pro__M01122	ZNF219 (directAnnotation).
ID1	tfdimers__MD00516	SOX10 (directAnnotation).
ID1	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
ID1	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
ID1	taipale_cyt_meth__LBX2_CTMATTAATTAN_eDBD	LBX2 (directAnnotation).
ID1	transfac_pro__M06907	ZFP3 (inferredBy_Orthology).
ID1	metacluster_9.13	LHX8 (directAnnotation).
ID1	metacluster_26.2	ZNF264 (directAnnotation). NKX2-8 (inferredBy_Orthology).
ID1	jaspar__MA1933.1	SREBF2 (directAnnotation).
ID1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
ID1	transfac_public__M00041	ATF2; JUN (directAnnotation).
ID1	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
ID1	transfac_pro__M06995	NFE2L3 (directAnnotation).
ID1	metacluster_155.3	PLAG1 (directAnnotation). PLAG1 (inferredBy_Orthology).
ID1	hocomoco__PDX1_MOUSE.H11MO.0.B	PDX1 (inferredBy_Orthology).
ID1	metacluster_22.17	NFE2 (directAnnotation).
ID1	taipale_tf_pairs__ELK1_HOXA3_NCCGGWNNNNNNNNNNNSCATTAN_CAP_repr	ELK1; HOXA3 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."