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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ICMT

Summary for ICMT

Gene information	Gene symbol	ICMT
	Ensembl ID	ENSG00000116237
	Entrez ID	23463
	Gene name	isoprenylcysteine carboxyl methyltransferase
	Synonyms	HSTE14\|PCCMT\|PPMT
	Gene type	protein_coding
	UniProtAcc	O60725

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Dataset with differentially expressed gene: ICMT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.305895	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.428328	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.486516	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.293129	0.00e+00

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Expression of ICMT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ICMT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ICMT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ICMT	hsa-miR-3658	98.9134	NM_012405
ICMT	hsa-miR-6508-5p	93.0189	NM_012405
ICMT	hsa-miR-6516-5p	91.9868	NM_012405
ICMT	hsa-miR-8067	91.9316	NM_012405
ICMT	hsa-miR-9-5p	86.9609	NM_012405
ICMT	hsa-miR-4495	86.5775	NM_012405
ICMT	hsa-miR-9-3p	86.4276	NM_012405
ICMT	hsa-miR-940	85.9425	NM_012405
ICMT	hsa-miR-6893-5p	85.9425	NM_012405
ICMT	hsa-miR-6808-5p	85.9425	NM_012405
ICMT	hsa-miR-1236-5p	85.8117	NM_012405
ICMT	hsa-miR-548ad-3p	84.5432	NM_012405
ICMT	hsa-miR-6841-3p	84.5171	NM_012405
ICMT	hsa-miR-9902	84.3952	NM_012405
ICMT	hsa-miR-580-3p	84.1127	NM_012405
ICMT	hsa-miR-4328	83.6858	NM_012405
ICMT	hsa-miR-6748-3p	82.7168	NM_012405
ICMT	hsa-miR-3714	82.6488	NM_012405
ICMT	hsa-miR-7109-3p	82.4743	NM_012405
ICMT	hsa-miR-5197-3p	81.8818	NM_012405
ICMT	hsa-miR-6716-5p	80.9791	NM_012405
ICMT	hsa-miR-4447	80.4057	NM_012405
ICMT	hsa-miR-3148	80.4018	NM_012405
ICMT	hsa-miR-10398-5p	80.3377	NM_012405

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Motifs and transcription factors (TFs) regulating ICMT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ICMT	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
ICMT	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ICMT	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ICMT	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ICMT	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ICMT	swissregulon__hs__ELF2	ELF2 (directAnnotation).
ICMT	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
ICMT	cisbp__M08198	ELF1 (directAnnotation).
ICMT	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."