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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IBTK

Summary for IBTK

Gene information	Gene symbol	IBTK
	Ensembl ID	ENSG00000283068
	Entrez ID	25998
	Gene name	inhibitor of Bruton tyrosine kinase
	Synonyms	BTBD26\|BTKI\|DKFZP564B116
	Gene type	protein_coding
	UniProtAcc	Q9P2D0

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Dataset with differentially expressed gene: IBTK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.334321	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.358868	2.54e-14

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Expression of IBTK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IBTK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IBTK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IBTK	hsa-miR-302c-5p	97.5592	NM_001300906
IBTK	hsa-miR-3190-5p	97.194	NM_001300906
IBTK	hsa-miR-342-3p	94.389	NM_015525
IBTK	hsa-miR-1468-3p	91.2375	NM_015525
IBTK	hsa-miR-4251	90.3595	NM_015525
IBTK	hsa-miR-17-3p	90.0036	NM_015525
IBTK	hsa-miR-12125	89.7354	NM_015525
IBTK	hsa-miR-9902	87.2212	NM_001300906
IBTK	hsa-miR-92b-3p	86.7525	NM_001300906
IBTK	hsa-miR-92a-3p	86.7525	NM_001300906
IBTK	hsa-miR-32-5p	86.7525	NM_001300906
IBTK	hsa-miR-587	86.2612	NM_015525
IBTK	hsa-miR-3606-5p	86.1358	NM_015525
IBTK	hsa-miR-363-3p	86.0161	NM_001300906
IBTK	hsa-miR-367-3p	86.0161	NM_001300906
IBTK	hsa-miR-25-3p	86.0161	NM_001300906
IBTK	hsa-miR-514b-5p	85.1229	NM_015525
IBTK	hsa-miR-513c-5p	85.1229	NM_015525
IBTK	hsa-miR-153-5p	84.5376	NM_015525
IBTK	hsa-miR-219b-3p	84.5068	NM_001300906
IBTK	hsa-miR-4705	83.6819	NM_001300906
IBTK	hsa-miR-892c-5p	83.588	NM_015525
IBTK	hsa-miR-3187-3p	83.1222	NM_001300906
IBTK	hsa-miR-1260a	82.507	NM_015525
IBTK	hsa-miR-1260b	82.507	NM_015525
IBTK	hsa-miR-302f	82.1898	NM_001300906
IBTK	hsa-miR-4529-5p	81.4154	NM_001300906
IBTK	hsa-miR-450b-5p	80.4861	NM_015525
IBTK	hsa-miR-3920	80.2446	NM_015525

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Motifs and transcription factors (TFs) regulating IBTK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IBTK	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
IBTK	transfac_pro__M06213	ZNF267 (directAnnotation).
IBTK	transfac_pro__M06035	ZNF749 (directAnnotation).
IBTK	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
IBTK	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
IBTK	metacluster_52.11	ZNF184 (directAnnotation).
IBTK	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
IBTK	tfdimers__MD00038	TFAP2C (directAnnotation).
IBTK	metacluster_7.13	ZFX (directAnnotation).
IBTK	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
IBTK	cisbp__M00968	MTF2 (directAnnotation).
IBTK	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
IBTK	metacluster_160.20	JUND; PRDM15 (directAnnotation).
IBTK	cisbp__M00341	PAX6 (directAnnotation).
IBTK	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
IBTK	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
IBTK	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
IBTK	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
IBTK	cisbp__M00788	ZFY (inferredBy_Orthology).
IBTK	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
IBTK	metacluster_175.1	ZNF283 (directAnnotation).
IBTK	hdpi__ZNF304	ZNF304 (directAnnotation).
IBTK	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
IBTK	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
IBTK	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
IBTK	transfac_pro__M01199	TRIM28 (directAnnotation).
IBTK	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
IBTK	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
IBTK	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
IBTK	transfac_pro__M03806	ZBTB7C (directAnnotation).
IBTK	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."