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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HSPH1

Summary for HSPH1

Gene information	Gene symbol	HSPH1
	Ensembl ID	ENSG00000120694
	Entrez ID	10808
	Gene name	heat shock protein family H (Hsp110) member 1
	Synonyms	HSP105A\|HSP105B\|KIAA0201\|NY-CO-25
	Gene type	protein_coding
	UniProtAcc	Q92598

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Dataset with differentially expressed gene: HSPH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.262791	5.87e-08
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.434636	2.75e-19
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	-0.423238	2.48e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	0.460173	4.95e-38
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.616738	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.634536	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.354502	1.62e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.412371	4.41e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	1.20855	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.96838	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	1.08128	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	1.11192	2.87e-31
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.313278	4.23e-18
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.452213	1.26e-44
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.374698	7.98e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.328136	1.41e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	-1.26222	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	-0.301022	1.33e-21
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	-0.361353	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	-0.658714	2.08e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	-0.333649	1.03e-11
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-1.60986	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-2.12542	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-1.18561	4.60e-10
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	-1.01199	9.04e-06
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	1.04744	1.95e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	1.00866	6.27e-23
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Progenitors	0.372832	3.13e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.309155	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.374452	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.486005	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	-0.278503	2.05e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.369763	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.400028	2.88e-23
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.536727	1.45e-26
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.365182	7.06e-13
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.525444	3.83e-23
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.439197	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.75319	1.41e-12
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.267244	0.00e+00

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Expression of HSPH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HSPH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HSPH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HSPH1	hsa-miR-3662	96.1389	NM_001286505
HSPH1	hsa-miR-4446-5p	94.686	NM_001286505
HSPH1	hsa-miR-4801	94.5922	NM_001286503
HSPH1	hsa-miR-5196-3p	94.1588	NM_001286503
HSPH1	hsa-miR-4282	94.0757	NM_001286505
HSPH1	hsa-miR-330-3p	93.9721	NM_001286503
HSPH1	hsa-miR-4470	93.0421	NM_001286503
HSPH1	hsa-miR-4731-3p	92.989	NM_001286503
HSPH1	hsa-miR-548p	92.164	NM_001286503
HSPH1	hsa-miR-4755-5p	90.2632	NM_001286505
HSPH1	hsa-miR-5006-3p	90.2632	NM_001286505
HSPH1	hsa-miR-9-3p	90.2099	NM_001286503
HSPH1	hsa-miR-601	89.8046	NM_001286505
HSPH1	hsa-miR-340-5p	89.7544	NM_001286503
HSPH1	hsa-miR-6807-5p	88.2036	NM_001286505
HSPH1	hsa-miR-374c-5p	87.6947	NM_001286503
HSPH1	hsa-miR-655-3p	87.6947	NM_001286503
HSPH1	hsa-miR-369-3p	87.2492	NM_001286503
HSPH1	hsa-miR-338-5p	87.1182	NM_001286503
HSPH1	hsa-miR-651-5p	86.8461	NM_001286505
HSPH1	hsa-miR-5680	86.3199	NM_001286503
HSPH1	hsa-miR-499b-5p	86.2494	NM_001286505
HSPH1	hsa-miR-4698	85.99	NM_001286505
HSPH1	hsa-miR-4766-5p	85.9417	NM_001286505
HSPH1	hsa-miR-9985	85.6065	NM_001286505
HSPH1	hsa-miR-27b-3p	85.6065	NM_001286505
HSPH1	hsa-miR-27a-3p	85.6065	NM_001286505
HSPH1	hsa-miR-219a-2-3p	85.4669	NM_001286505
HSPH1	hsa-miR-548z	85.2573	NM_001286505
HSPH1	hsa-miR-548ac	85.2573	NM_001286505
HSPH1	hsa-miR-548h-3p	85.2573	NM_001286505
HSPH1	hsa-miR-548d-3p	85.2573	NM_001286505
HSPH1	hsa-miR-548bb-3p	85.2573	NM_001286505
HSPH1	hsa-miR-6813-3p	83.3409	NM_001286503
HSPH1	hsa-miR-4520-3p	83.0963	NM_001286505
HSPH1	hsa-miR-10527-5p	82.6889	NM_001286503
HSPH1	hsa-miR-320d	82.3354	NM_001286503
HSPH1	hsa-miR-320c	82.3354	NM_001286503
HSPH1	hsa-miR-320a-3p	82.3354	NM_001286503
HSPH1	hsa-miR-320b	82.3354	NM_001286503
HSPH1	hsa-miR-4429	82.3354	NM_001286503
HSPH1	hsa-miR-548c-3p	81.9123	NM_001286505
HSPH1	hsa-miR-511-3p	81.7684	NM_001286505
HSPH1	hsa-miR-3121-3p	81.5126	NM_001286505
HSPH1	hsa-miR-889-3p	81.4599	NM_001286503
HSPH1	hsa-miR-921	81.0071	NM_001286505
HSPH1	hsa-miR-4709-5p	80.7726	NM_001286505
HSPH1	hsa-miR-142-5p	80.5716	NM_001286505
HSPH1	hsa-miR-5590-3p	80.5716	NM_001286505

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Motifs and transcription factors (TFs) regulating HSPH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HSPH1	hdpi__ETV4	ETV4 (directAnnotation).
HSPH1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
HSPH1	transfac_pro__M06156	ZNF75D (directAnnotation).
HSPH1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
HSPH1	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
HSPH1	hdpi__TP73	TP73 (directAnnotation).
HSPH1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
HSPH1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
HSPH1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
HSPH1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
HSPH1	metacluster_56.5	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
HSPH1	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
HSPH1	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
HSPH1	homer__TAATCCCN_Pitx1	PITX1 (inferredBy_Orthology).
HSPH1	taipale_tf_pairs__GCM1_HOXA2_RTRSGGGNNTAATKR_CAP_repr	GCM1; HOXA2 (directAnnotation).
HSPH1	metacluster_21.4	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
HSPH1	transfac_pro__M05483	ZBTB1 (directAnnotation).
HSPH1	metacluster_56.3	HSF2 (directAnnotation).
HSPH1	taipale_tf_pairs__TEAD4_HOXB13_NTCGTAAAATGC_CAP	HOXB13; TEAD4 (directAnnotation).
HSPH1	transfac_pro__M06927	EBF2 (inferredBy_Orthology).
HSPH1	transfac_pro__M05846	ZNF689 (directAnnotation).
HSPH1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
HSPH1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
HSPH1	hdpi__ZNF304	ZNF304 (directAnnotation).
HSPH1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
HSPH1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
HSPH1	transfac_pro__M06032	ZNF727 (directAnnotation).
HSPH1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
HSPH1	hdpi__ELF2	ELF2 (directAnnotation).
HSPH1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
HSPH1	metacluster_81.7	CREB1 (directAnnotation).
HSPH1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
HSPH1	taipale_tf_pairs__MYBL1_MAX_YAACGGNNNNNNNNNNCACGTG_CAP_repr	MAX; MYBL1 (directAnnotation).
HSPH1	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
HSPH1	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
HSPH1	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
HSPH1	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
HSPH1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
HSPH1	taipale_tf_pairs__POU2F1_ETV1_NCCGGATATGCAN_CAP_repr	ETV1; POU2F1 (directAnnotation).
HSPH1	transfac_pro__M05871	ZNF565 (directAnnotation).
HSPH1	transfac_pro__M05981	ZNF233 (directAnnotation).
HSPH1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
HSPH1	transfac_pro__M06135	ZNF28 (directAnnotation).
HSPH1	metacluster_172.6	CHD2; E2F1 (directAnnotation).
HSPH1	transfac_pro__M06141	ZNF708 (directAnnotation).
HSPH1	transfac_pro__M06071	ZNF814 (directAnnotation).
HSPH1	transfac_pro__M06035	ZNF749 (directAnnotation).
HSPH1	transfac_pro__M06229	ZNF91 (directAnnotation).
HSPH1	transfac_pro__M06463	ZNF595 (directAnnotation).
HSPH1	jaspar__MA1951.1	FOS (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HSPH1	"Phenethyl Isothiocyanate"	DB12695	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."