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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HSPA4L

Summary for HSPA4L

Gene information	Gene symbol	HSPA4L
	Ensembl ID	ENSG00000164070
	Entrez ID	22824
	Gene name	heat shock protein family A (Hsp70) member 4 like
	Synonyms	APG-1\|HSPH3\|Osp94
	Gene type	protein_coding
	UniProtAcc	O95757

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Dataset with differentially expressed gene: HSPA4L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.02622	4.30e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.409477	5.91e-24

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Expression of HSPA4L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HSPA4L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HSPA4L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HSPA4L	hsa-miR-411-3p	99.6928	NM_001317381
HSPA4L	hsa-miR-379-3p	99.6928	NM_001317381
HSPA4L	hsa-miR-607	95.7991	NM_001317381
HSPA4L	hsa-miR-4495	95.7828	NM_001317381
HSPA4L	hsa-miR-708-3p	95.6656	NM_001317381
HSPA4L	hsa-miR-8087	94.9726	NM_001317381
HSPA4L	hsa-miR-3140-5p	94.1367	NM_001317381
HSPA4L	hsa-miR-195-5p	93.6751	NM_001317381
HSPA4L	hsa-miR-16-5p	92.8461	NM_001317381
HSPA4L	hsa-miR-15b-5p	92.8461	NM_001317381
HSPA4L	hsa-miR-15a-5p	92.8461	NM_001317381
HSPA4L	hsa-miR-380-3p	92.7286	NM_001317381
HSPA4L	hsa-miR-497-5p	92.2178	NM_001317381
HSPA4L	hsa-miR-424-5p	92.2178	NM_001317381
HSPA4L	hsa-miR-6838-5p	92.2178	NM_001317381
HSPA4L	hsa-miR-194-5p	91.8073	NM_001317381
HSPA4L	hsa-miR-6501-5p	91.2505	NM_001317381
HSPA4L	hsa-miR-4772-3p	90.0943	NM_001317381
HSPA4L	hsa-miR-183-3p	89.9047	NM_001317381
HSPA4L	hsa-miR-3145-5p	89.5618	NM_001317381
HSPA4L	hsa-miR-1305	87.5679	NM_001317381
HSPA4L	hsa-miR-3658	87.4429	NM_001317381
HSPA4L	hsa-miR-8067	86.8076	NM_001317381
HSPA4L	hsa-miR-6508-5p	86.8076	NM_001317381
HSPA4L	hsa-miR-570-5p	85.738	NM_001317381
HSPA4L	hsa-miR-548ai	85.738	NM_001317381
HSPA4L	hsa-miR-548ba	85.738	NM_001317381
HSPA4L	hsa-miR-548ag	85.738	NM_001317381
HSPA4L	hsa-miR-8066	85.737	NM_001317381
HSPA4L	hsa-miR-6796-3p	84.8372	NM_001317381
HSPA4L	hsa-miR-5700	84.5074	NM_001317381
HSPA4L	hsa-miR-579-3p	84.0763	NM_001317381
HSPA4L	hsa-miR-664b-3p	84.0763	NM_001317381
HSPA4L	hsa-miR-1323	83.6157	NM_001317381
HSPA4L	hsa-miR-146b-3p	82.8268	NM_001317381
HSPA4L	hsa-miR-3143	82.7265	NM_001317381
HSPA4L	hsa-miR-1255b-2-3p	82.0224	NM_001317381
HSPA4L	hsa-miR-5093	81.7625	NM_001317381
HSPA4L	hsa-miR-3177-5p	81.486	NM_001317381
HSPA4L	hsa-miR-548o-3p	80.9694	NM_001317381
HSPA4L	hsa-miR-5000-3p	80.801	NM_001317381
HSPA4L	hsa-miR-606	80.7886	NM_001317381
HSPA4L	hsa-miR-4251	80.5184	NM_001317381

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Motifs and transcription factors (TFs) regulating HSPA4L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HSPA4L	metacluster_135.11	NR2C2 (directAnnotation).
HSPA4L	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
HSPA4L	tfdimers__MD00038	TFAP2C (directAnnotation).
HSPA4L	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
HSPA4L	metacluster_7.13	ZFX (directAnnotation).
HSPA4L	cisbp__M00968	MTF2 (directAnnotation).
HSPA4L	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
HSPA4L	metacluster_160.20	JUND; PRDM15 (directAnnotation).
HSPA4L	metacluster_198.3	ZFP64 (directAnnotation).
HSPA4L	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
HSPA4L	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
HSPA4L	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
HSPA4L	cisbp__M00788	ZFY (inferredBy_Orthology).
HSPA4L	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
HSPA4L	metacluster_175.1	ZNF283 (directAnnotation).
HSPA4L	hdpi__ZNF304	ZNF304 (directAnnotation).
HSPA4L	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
HSPA4L	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
HSPA4L	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
HSPA4L	transfac_pro__M01199	TRIM28 (directAnnotation).
HSPA4L	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
HSPA4L	metacluster_151.2	ZNF23 (directAnnotation).
HSPA4L	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
HSPA4L	transfac_pro__M03806	ZBTB7C (directAnnotation).
HSPA4L	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."