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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HSPA13

Summary for HSPA13

Gene information	Gene symbol	HSPA13
	Ensembl ID	ENSG00000155304
	Entrez ID	6782
	Gene name	heat shock protein family A (Hsp70) member 13
	Synonyms	STCH
	Gene type	protein_coding
	UniProtAcc	P48723

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Dataset with differentially expressed gene: HSPA13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.314336	4.66e-23
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.288372	0.00e+00

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Expression of HSPA13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HSPA13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HSPA13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HSPA13	hsa-miR-4719	98.4584	NM_006948
HSPA13	hsa-miR-33a-3p	96.529	NM_006948
HSPA13	hsa-miR-4482-3p	95.747	NM_006948
HSPA13	hsa-miR-9902	95.0171	NM_006948
HSPA13	hsa-miR-4495	94.6341	NM_006948
HSPA13	hsa-miR-3671	92.7851	NM_006948
HSPA13	hsa-miR-5011-5p	91.8909	NM_006948
HSPA13	hsa-miR-4679	91.3444	NM_006948
HSPA13	hsa-miR-371a-5p	90.4886	NM_006948
HSPA13	hsa-miR-4700-3p	89.8576	NM_006948
HSPA13	hsa-miR-3925-5p	89.2092	NM_006948
HSPA13	hsa-miR-4775	88.5585	NM_006948
HSPA13	hsa-miR-429	88.5171	NM_006948
HSPA13	hsa-miR-200b-3p	88.5171	NM_006948
HSPA13	hsa-miR-200c-3p	88.5171	NM_006948
HSPA13	hsa-miR-190a-3p	87.7665	NM_006948
HSPA13	hsa-miR-4666a-3p	87.5833	NM_006948
HSPA13	hsa-miR-5000-3p	87.2682	NM_006948
HSPA13	hsa-miR-205-5p	85.69	NM_006948
HSPA13	hsa-miR-3941	85.217	NM_006948
HSPA13	hsa-miR-561-3p	84.8764	NM_006948
HSPA13	hsa-miR-6504-3p	83.6915	NM_006948
HSPA13	hsa-miR-10399-5p	83.6915	NM_006948
HSPA13	hsa-miR-548au-3p	83.5468	NM_006948
HSPA13	hsa-miR-651-3p	83.4586	NM_006948
HSPA13	hsa-miR-3928-3p	82.8603	NM_006948
HSPA13	hsa-miR-570-3p	82.6589	NM_006948
HSPA13	hsa-miR-3689a-5p	81.9578	NM_006948
HSPA13	hsa-miR-3689e	81.9578	NM_006948
HSPA13	hsa-miR-3689f	81.9578	NM_006948
HSPA13	hsa-miR-3689b-5p	81.9578	NM_006948
HSPA13	hsa-miR-4772-5p	81.2734	NM_006948
HSPA13	hsa-miR-8485	81.263	NM_006948
HSPA13	hsa-miR-12123	81.2478	NM_006948
HSPA13	hsa-miR-450b-5p	80.5836	NM_006948
HSPA13	hsa-miR-4799-5p	80.5403	NM_006948

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Motifs and transcription factors (TFs) regulating HSPA13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HSPA13	transfac_pro__M06213	ZNF267 (directAnnotation).
HSPA13	metacluster_98.1	ZNF524 (directAnnotation).
HSPA13	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HSPA13	"Copper"	DB09130	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."