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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HSF2BP

Summary for HSF2BP

Gene information	Gene symbol	HSF2BP
	Ensembl ID	ENSG00000160207
	Entrez ID	11077
	Gene name	heat shock transcription factor 2 binding protein
	Synonyms	MEILB2
	Gene type	protein_coding
	UniProtAcc	O75031

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Dataset with differentially expressed gene: HSF2BP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.499464	0.00e+00

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Expression of HSF2BP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HSF2BP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HSF2BP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HSF2BP	hsa-miR-12123	98.1639	NM_007031
HSF2BP	hsa-miR-4272	95.4651	NM_007031
HSF2BP	hsa-miR-7109-5p	95.3357	NM_007031
HSF2BP	hsa-miR-3613-3p	95.0968	NM_007031
HSF2BP	hsa-miR-8069	94.8148	NM_007031
HSF2BP	hsa-miR-12135	87.042	NM_007031
HSF2BP	hsa-miR-4654	86.4787	NM_007031
HSF2BP	hsa-miR-299-3p	84.3121	NM_007031
HSF2BP	hsa-miR-154-5p	84.2695	NM_007031
HSF2BP	hsa-miR-6887-5p	84.1607	NM_007031
HSF2BP	hsa-miR-6795-5p	84.1607	NM_007031
HSF2BP	hsa-miR-4700-5p	82.9955	NM_007031
HSF2BP	hsa-miR-4769-5p	81.5185	NM_007031

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Motifs and transcription factors (TFs) regulating HSF2BP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HSF2BP	transfac_pro__M04950	EGR1 (directAnnotation).
HSF2BP	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
HSF2BP	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."