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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HSDL2

Summary for HSDL2

Gene information	Gene symbol	HSDL2
	Ensembl ID	ENSG00000119471
	Entrez ID	84263
	Gene name	hydroxysteroid dehydrogenase like 2
	Synonyms	C9orf99\|SDR13C1
	Gene type	protein_coding
	UniProtAcc	Q6YN16

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Dataset with differentially expressed gene: HSDL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.317169	2.08e-19
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.351534	5.33e-20

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Expression of HSDL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HSDL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HSDL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HSDL2	hsa-miR-4527	95.5122	NM_001195822
HSDL2	hsa-miR-6503-5p	93.8794	NM_001195822
HSDL2	hsa-miR-432-5p	93.346	NM_001195822
HSDL2	hsa-miR-3119	92.2999	NM_001195822
HSDL2	hsa-miR-101-5p	91.8772	NM_001195822
HSDL2	hsa-miR-516b-5p	89.1874	NM_001195822
HSDL2	hsa-miR-5688	88.8589	NM_001195822
HSDL2	hsa-miR-495-3p	88.8589	NM_001195822
HSDL2	hsa-miR-3911	86.7197	NM_001195822
HSDL2	hsa-miR-6849-3p	86.3756	NM_001195822
HSDL2	hsa-miR-203a-3p	85.5788	NM_001195822
HSDL2	hsa-miR-5003-3p	85.4568	NM_001195822
HSDL2	hsa-miR-4698	85.1698	NM_001195822
HSDL2	hsa-miR-8055	85.0003	NM_001195822
HSDL2	hsa-miR-6165	83.3458	NM_001195822
HSDL2	hsa-miR-140-3p	83.3305	NM_001195822
HSDL2	hsa-miR-147a	82.8126	NM_001195822
HSDL2	hsa-miR-6072	81.3642	NM_001195822
HSDL2	hsa-miR-12129	80.8134	NM_001195822
HSDL2	hsa-miR-8056	80.5953	NM_001195822

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Motifs and transcription factors (TFs) regulating HSDL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HSDL2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
HSDL2	transfac_pro__M00652	NRF1 (directAnnotation).
HSDL2	cisbp__M00341	PAX6 (directAnnotation).
HSDL2	jaspar__MA1650.1	ZBTB14 (directAnnotation).
HSDL2	transfac_pro__M03806	ZBTB7C (directAnnotation).
HSDL2	transfac_pro__M01253	CNOT3 (directAnnotation).
HSDL2	metacluster_175.5	IRX3; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP63; TP63; TP63; TP63; TP63; TP63; TP73; TP73; TP73; TP73; TP73; TP73 (directAnnotation). TP53; TP53; TP53; TP73 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."