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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HSD17B12

Summary for HSD17B12

Gene information	Gene symbol	HSD17B12
	Ensembl ID	ENSG00000149084
	Entrez ID	51144
	Gene name	hydroxysteroid 17-beta dehydrogenase 12
	Synonyms	KAR\|SDR12C1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HSD17B12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.529489	1.40e-45
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.363382	0.00e+00

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Expression of HSD17B12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HSD17B12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HSD17B12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HSD17B12	hsa-miR-586	95.1033	NM_016142
HSD17B12	hsa-miR-3190-5p	94.7219	NM_016142
HSD17B12	hsa-miR-579-3p	93.9625	NM_016142
HSD17B12	hsa-miR-664b-3p	93.9625	NM_016142
HSD17B12	hsa-miR-6813-5p	90.789	NM_016142
HSD17B12	hsa-miR-6085	90.789	NM_016142
HSD17B12	hsa-miR-9851-5p	90.4587	NM_016142
HSD17B12	hsa-miR-27b-3p	90.1633	NM_016142
HSD17B12	hsa-miR-27a-3p	90.1633	NM_016142
HSD17B12	hsa-miR-9985	90.1633	NM_016142
HSD17B12	hsa-miR-1253	88.3272	NM_016142
HSD17B12	hsa-miR-548at-3p	87.831	NM_016142
HSD17B12	hsa-miR-548ay-3p	87.831	NM_016142
HSD17B12	hsa-miR-6881-3p	87.7616	NM_016142
HSD17B12	hsa-miR-9902	85.8255	NM_016142
HSD17B12	hsa-miR-4272	85.7359	NM_016142
HSD17B12	hsa-miR-3919	85.5484	NM_016142
HSD17B12	hsa-miR-1537-3p	85.1098	NM_016142
HSD17B12	hsa-miR-4489	84.6486	NM_016142
HSD17B12	hsa-miR-4482-3p	82.3348	NM_016142
HSD17B12	hsa-miR-6789-5p	81.4938	NM_016142
HSD17B12	hsa-miR-335-3p	81.2102	NM_016142
HSD17B12	hsa-miR-3059-5p	80.5539	NM_016142

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Motifs and transcription factors (TFs) regulating HSD17B12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HSD17B12	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
HSD17B12	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
HSD17B12	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
HSD17B12	jaspar__MA0502.2	NFYB (directAnnotation).
HSD17B12	metacluster_7.13	ZFX (directAnnotation).
HSD17B12	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
HSD17B12	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
HSD17B12	cisbp__M01863	ZNF711 (inferredBy_Orthology).
HSD17B12	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
HSD17B12	transfac_pro__M02861	GATA6 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."