Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE140440 | DU145 and PCÂ cell lines | Cell line | Prostate cancer | Prostate cancer | Chemotherapy | docetaxel | NA | Malignant cells | 1.03586 | 1.36e-18 |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | 0.274293 | 0.00e+00 |
GSE163836 | FCIBC02 cell line | Cell line | Breast cancer | Inflammatory breast cancer | Chemotherapy | paclitaxel | NA | Malignant cells | -0.322834 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | cDCs | -0.277627 | 8.04e-03 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | Mono/Macro | -0.371229 | 0.00e+00 |
GSE153697 | patients | Bone marrow aspirate | Acute lymphoblastic leukemia | Relapsed B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | anti-CD19 CAR-T | NA | Malignant cells | 0.399688 | 9.61e-31 |
GSE197268_Tisa-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | tisa-cel (CAR-T) | pre | Mono/Macro | 0.325146 | 0.00e+00 |
GSE189460 | patients | Bone marrow aspirate | Multiple myeloma | Multiple myeloma (MM) | Targeted therapy | bortezomib + melphalan + prednisolone | pre | Malignant cells | -0.258786 | 0.00e+00 |
GSE168668 | LNCaP cell line | Cell line | Prostate cancer | Prostate cancer | Targeted therapy | enzalutamide | NA | Malignant cells | 0.393006 | 0.00e+00 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | post | Erythrocytes | 0.353637 | 1.73e-02 |
GSE131984_JQ1Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + paclitaxel | NA | Malignant cells | -0.269487 | 1.20e-16 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | -0.651286 | 0.00e+00 |
GSE108397 | 451Lu cell line | Cell line | Melanoma | Melanoma | Targeted therapy | PLX-4720 | NA | Malignant cells | 0.459433 | 0.00e+00 |
GSE115251 | Kelly cell line | Cell line | Neuroblastoma | Neuroblastoma | Targeted therapy | TAE684 | NA | Malignant cells | -0.84113 | 0.00e+00 |
GSE164897_VemCob | A375 cell line | Cell line | Melanoma | BRAFV600E-mutant melanoma | Targeted therapy | vemurafenib + combimetinib | NA | Malignant cells | 0.774061 | 0.00e+00 |
GSE164897_VemTra | A375 cell line | Cell line | Melanoma | B+E2:E57RAFV600E-mutant melanoma | Targeted therapy | vemurafenib + trametinib | NA | Malignant cells | 0.634577 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
HSBP1 | metacluster_191.2 | ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology). |
HSBP1 | taipale_tf_pairs__ETS2_RCCGGAAGTG_HT | ETS2 (directAnnotation). |
HSBP1 | metacluster_166.4 | BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology). |
HSBP1 | taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr | ELF1; MEIS1 (directAnnotation). |
HSBP1 | metacluster_191.3 | EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology). |
HSBP1 | taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr | ELK1; TBX21 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP | ETV5; HOXA2 (directAnnotation). |
HSBP1 | hdpi__ETV4 | ETV4 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP | ELK1; TEF (directAnnotation). |
HSBP1 | taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP | ELK3; FOXO1 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP | EOMES; ETV5 (directAnnotation). |
HSBP1 | taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP | ELK1; FOXO1 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ETV2_TCF3_CASSTGNNCCGGAWRYN_CAP_repr | ETV2; TCF3 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP | ELK1; EOMES (directAnnotation). |
HSBP1 | metacluster_138.2 | ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology). |
HSBP1 | transfac_pro__M02843 | BBX (inferredBy_Orthology). |
HSBP1 | transfac_pro__M02090 | E2F4 (directAnnotation). |
HSBP1 | transfac_public__M00491 | PATZ1 (directAnnotation). |
HSBP1 | metacluster_195.2 | EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology). |
HSBP1 | metacluster_170.2 | KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology). |
HSBP1 | metacluster_34.4 | ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology). |
HSBP1 | transfac_pro__M04826 | EP300 (directAnnotation). |
HSBP1 | transfac_pro__M04944 | GABPA (directAnnotation). |
HSBP1 | metacluster_34.3 | EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation). |
HSBP1 | transfac_pro__M05817 | ZNF546 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr | ERF; FOXI1 (directAnnotation). |
HSBP1 | metacluster_166.2 | ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology). |
HSBP1 | taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT | ELK1; HOXA1 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP | ELK1; FOXI1 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr | ERF; FOXI1 (directAnnotation). |
HSBP1 | taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr | ELK1; HOXB2 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr | DRGX; ETV2 (directAnnotation). |
HSBP1 | jaspar__MA1509.1 | IRF6 (directAnnotation). |
HSBP1 | metacluster_2.8 | IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology). |
HSBP1 | transfac_pro__M05743 | ZNF57 (directAnnotation). |
HSBP1 | taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth | IRF6 (directAnnotation). |
HSBP1 | metacluster_22.1 | MAFF (inferredBy_Orthology). |
HSBP1 | taipale_tf_pairs__FLI1_MAX_RSCGGAANCACGTGN_CAP | FLI1; MAX (directAnnotation). |
HSBP1 | jaspar__MA1708.1 | ETV7 (directAnnotation). |
HSBP1 | taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth | ZNF385D (directAnnotation). |
HSBP1 | swissregulon__hs__ELK1 | ELK1 (directAnnotation). |
HSBP1 | taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr | E2F1; ELK1 (directAnnotation). |
HSBP1 | taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP | ETV5; HOXB13 (directAnnotation). |
HSBP1 | transfac_pro__M04887 | TCF12 (directAnnotation). |
HSBP1 | transfac_pro__M06130 | ZNF254 (directAnnotation). |
HSBP1 | transfac_pro__M06692 | PRDM10 (directAnnotation). |
HSBP1 | transfac_pro__M06369 | ZFP1 (directAnnotation). |
HSBP1 | tfdimers__MD00031 | MYB; ZEB1 (directAnnotation). |
HSBP1 | tfdimers__MD00351 | IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation). |
HSBP1 | transfac_pro__M05838 | ZNF550 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |