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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HS3ST1

Summary for HS3ST1

Gene information	Gene symbol	HS3ST1
	Ensembl ID	ENSG00000002587
	Entrez ID	9957
	Gene name	heparan sulfate-glucosamine 3-sulfotransferase 1
	Synonyms	3OST1
	Gene type	protein_coding
	UniProtAcc	O14792

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Dataset with differentially expressed gene: HS3ST1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.47435	4.94e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.388504	0.00e+00

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Expression of HS3ST1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HS3ST1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HS3ST1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HS3ST1	hsa-miR-4290	96.8135	NM_005114
HS3ST1	hsa-miR-205-5p	94.581	NM_005114
HS3ST1	hsa-miR-8076	93.9264	NM_005114
HS3ST1	hsa-miR-4760-5p	92.9367	NM_005114
HS3ST1	hsa-miR-5697	92.0862	NM_005114
HS3ST1	hsa-miR-1183	90.9993	NM_005114
HS3ST1	hsa-miR-1290	90.7206	NM_005114
HS3ST1	hsa-miR-8061	90.6768	NM_005114
HS3ST1	hsa-miR-6826-3p	90.5372	NM_005114
HS3ST1	hsa-miR-30d-3p	89.3232	NM_005114
HS3ST1	hsa-miR-30e-3p	89.3232	NM_005114
HS3ST1	hsa-miR-30a-3p	89.3232	NM_005114
HS3ST1	hsa-miR-524-5p	88.8774	NM_005114
HS3ST1	hsa-miR-520d-5p	88.8774	NM_005114
HS3ST1	hsa-miR-4276	88.7141	NM_005114
HS3ST1	hsa-miR-200b-3p	87.5122	NM_005114
HS3ST1	hsa-miR-200c-3p	87.5122	NM_005114
HS3ST1	hsa-miR-429	87.5122	NM_005114
HS3ST1	hsa-miR-6716-5p	85.9435	NM_005114
HS3ST1	hsa-miR-4303	84.3813	NM_005114
HS3ST1	hsa-let-7g-3p	81.6186	NM_005114
HS3ST1	hsa-let-7a-2-3p	81.6186	NM_005114

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Motifs and transcription factors (TFs) regulating HS3ST1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HS3ST1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
HS3ST1	jaspar__MA1125.1	ZNF384 (directAnnotation).
HS3ST1	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
HS3ST1	hdpi__TFAM	TFAM (directAnnotation).
HS3ST1	transfac_pro__M06072	ZNF623 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HS3ST1	"Adenosine 3',5'-diphosphate"	DB01812	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."