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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HOXD1

Summary for HOXD1

Gene information	Gene symbol	HOXD1
	Ensembl ID	ENSG00000128645
	Entrez ID	3231
	Gene name	homeobox D1
	Synonyms	HOX4\|HOX4G
	Gene type	protein_coding
	UniProtAcc	Q9GZZ0

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Dataset with differentially expressed gene: HOXD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.353736	0.00e+00

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Expression of HOXD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HOXD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HOXD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HOXD1	hsa-miR-6715b-5p	94.9586	NM_024501
HOXD1	hsa-miR-4269	94.9586	NM_024501
HOXD1	hsa-miR-670-5p	93.0323	NM_024501
HOXD1	hsa-miR-4666a-5p	91.1234	NM_024501
HOXD1	hsa-miR-7114-5p	90.6359	NM_024501
HOXD1	hsa-miR-4262	90.1679	NM_024501
HOXD1	hsa-miR-556-3p	89.7612	NM_024501
HOXD1	hsa-miR-4316	88.5943	NM_024501
HOXD1	hsa-miR-504-3p	88.4167	NM_024501
HOXD1	hsa-miR-4295	88.3478	NM_024501
HOXD1	hsa-miR-301b-3p	88.3478	NM_024501
HOXD1	hsa-miR-301a-3p	88.3478	NM_024501
HOXD1	hsa-miR-130a-3p	88.3478	NM_024501
HOXD1	hsa-miR-130b-3p	88.3478	NM_024501
HOXD1	hsa-miR-3666	88.3478	NM_024501
HOXD1	hsa-miR-454-3p	88.3478	NM_024501
HOXD1	hsa-miR-181b-5p	87.9073	NM_024501
HOXD1	hsa-miR-181d-5p	87.9073	NM_024501
HOXD1	hsa-miR-181a-5p	87.9073	NM_024501
HOXD1	hsa-miR-181c-5p	87.9073	NM_024501
HOXD1	hsa-miR-5582-5p	86.6349	NM_024501
HOXD1	hsa-miR-4500	86.3646	NM_024501
HOXD1	hsa-miR-646	86.0079	NM_024501
HOXD1	hsa-miR-4755-5p	83.6837	NM_024501
HOXD1	hsa-miR-5006-3p	83.6837	NM_024501
HOXD1	hsa-miR-98-5p	81.9231	NM_024501
HOXD1	hsa-let-7g-5p	81.9231	NM_024501
HOXD1	hsa-let-7b-5p	81.9231	NM_024501
HOXD1	hsa-let-7i-5p	81.9231	NM_024501
HOXD1	hsa-let-7e-5p	81.9231	NM_024501
HOXD1	hsa-miR-4458	81.9231	NM_024501
HOXD1	hsa-let-7c-5p	81.9231	NM_024501
HOXD1	hsa-let-7d-5p	81.9231	NM_024501
HOXD1	hsa-let-7a-5p	81.9231	NM_024501
HOXD1	hsa-let-7f-5p	81.9231	NM_024501
HOXD1	hsa-miR-1183	81.1284	NM_024501

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Motifs and transcription factors (TFs) regulating HOXD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HOXD1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
HOXD1	cisbp__M07938	E2F1 (directAnnotation).
HOXD1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."