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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HOXC8

Summary for HOXC8

Gene information	Gene symbol	HOXC8
	Ensembl ID	ENSG00000037965
	Entrez ID	3224
	Gene name	homeobox C8
	Synonyms	HOX3\|HOX3A
	Gene type	protein_coding
	UniProtAcc	P31273

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Dataset with differentially expressed gene: HOXC8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.54737	2.74e-03

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Expression of HOXC8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HOXC8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HOXC8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HOXC8	hsa-miR-4795-3p	99.999	NM_022658
HOXC8	hsa-miR-196b-5p	99.9737	NM_022658
HOXC8	hsa-miR-196a-5p	99.9737	NM_022658
HOXC8	hsa-miR-126-5p	99.9119	NM_022658
HOXC8	hsa-miR-4262	97.4729	NM_022658
HOXC8	hsa-miR-6509-5p	95.8808	NM_022658
HOXC8	hsa-miR-148b-3p	95.7993	NM_022658
HOXC8	hsa-miR-152-3p	95.7993	NM_022658
HOXC8	hsa-miR-148a-3p	95.7993	NM_022658
HOXC8	hsa-miR-181c-5p	95.4658	NM_022658
HOXC8	hsa-miR-181d-5p	95.4658	NM_022658
HOXC8	hsa-miR-181a-5p	95.4658	NM_022658
HOXC8	hsa-miR-181b-5p	95.4658	NM_022658
HOXC8	hsa-miR-26a-2-3p	94.377	NM_022658
HOXC8	hsa-miR-26a-1-3p	94.377	NM_022658
HOXC8	hsa-miR-4753-3p	93.9398	NM_022658
HOXC8	hsa-miR-130a-5p	93.9048	NM_022658
HOXC8	hsa-miR-6831-5p	93.1758	NM_022658
HOXC8	hsa-miR-548e-5p	93.1307	NM_022658
HOXC8	hsa-miR-6809-3p	92.9415	NM_022658
HOXC8	hsa-miR-3927-3p	92.2653	NM_022658
HOXC8	hsa-miR-3606-5p	92.2013	NM_022658
HOXC8	hsa-miR-3660	91.9237	NM_022658
HOXC8	hsa-miR-4526	91.9237	NM_022658
HOXC8	hsa-miR-34b-5p	91.8426	NM_022658
HOXC8	hsa-miR-449c-5p	91.8426	NM_022658
HOXC8	hsa-miR-4447	91.6783	NM_022658
HOXC8	hsa-miR-4660	90.447	NM_022658
HOXC8	hsa-miR-4303	90.1466	NM_022658
HOXC8	hsa-miR-2682-5p	90.089	NM_022658
HOXC8	hsa-miR-4686	89.5183	NM_022658
HOXC8	hsa-miR-6165	88.8368	NM_022658
HOXC8	hsa-miR-4778-3p	88.7575	NM_022658
HOXC8	hsa-miR-567	88.6707	NM_022658
HOXC8	hsa-miR-211-5p	88.2652	NM_022658
HOXC8	hsa-miR-204-5p	88.2652	NM_022658
HOXC8	hsa-miR-4666a-3p	88.1345	NM_022658
HOXC8	hsa-miR-331-5p	87.8844	NM_022658
HOXC8	hsa-miR-6719-3p	85.6053	NM_022658
HOXC8	hsa-miR-558	83.8713	NM_022658
HOXC8	hsa-miR-6730-3p	82.6174	NM_022658
HOXC8	hsa-miR-520d-5p	81.923	NM_022658
HOXC8	hsa-miR-524-5p	81.923	NM_022658
HOXC8	hsa-miR-4472	81.8933	NM_022658
HOXC8	hsa-miR-302c-5p	81.8238	NM_022658
HOXC8	hsa-miR-944	81.4908	NM_022658
HOXC8	hsa-miR-548ap-3p	81.1067	NM_022658
HOXC8	hsa-miR-548t-3p	81.1067	NM_022658
HOXC8	hsa-miR-548aa	81.1067	NM_022658
HOXC8	hsa-miR-3151-5p	80.5206	NM_022658

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Motifs and transcription factors (TFs) regulating HOXC8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."