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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HOXA9

Summary for HOXA9

Gene information	Gene symbol	HOXA9
	Ensembl ID	ENSG00000078399
	Entrez ID	3205
	Gene name	homeobox A9
	Synonyms	HOX1\|HOX1G
	Gene type	protein_coding
	UniProtAcc	P31269

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Dataset with differentially expressed gene: HOXA9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.53082	0.00e+00

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Expression of HOXA9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HOXA9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HOXA9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HOXA9	hsa-miR-5011-5p	99.443	NM_152739
HOXA9	hsa-miR-1185-1-3p	98.3952	NM_152739
HOXA9	hsa-miR-1185-2-3p	98.3952	NM_152739
HOXA9	hsa-let-7f-2-3p	98.3867	NM_152739
HOXA9	hsa-miR-300	97.9557	NM_152739
HOXA9	hsa-miR-381-3p	97.9557	NM_152739
HOXA9	hsa-miR-1468-3p	97.6004	NM_152739
HOXA9	hsa-miR-182-5p	96.5263	NM_152739
HOXA9	hsa-miR-95-5p	96.2635	NM_152739
HOXA9	hsa-miR-4666a-3p	96.1042	NM_152739
HOXA9	hsa-miR-196a-5p	96.001	NM_152739
HOXA9	hsa-miR-196b-5p	96.001	NM_152739
HOXA9	hsa-miR-548aw	95.9794	NM_152739
HOXA9	hsa-miR-548f-5p	95.3418	NM_152739
HOXA9	hsa-miR-190a-3p	94.7804	NM_152739
HOXA9	hsa-miR-6880-5p	94.6455	NM_152739
HOXA9	hsa-miR-6792-3p	94.629	NM_152739
HOXA9	hsa-miR-4691-5p	94.5733	NM_152739
HOXA9	hsa-miR-6831-5p	94.1326	NM_152739
HOXA9	hsa-let-7f-1-3p	93.3185	NM_152739
HOXA9	hsa-miR-98-3p	93.3185	NM_152739
HOXA9	hsa-let-7b-3p	93.3185	NM_152739
HOXA9	hsa-let-7a-3p	93.3185	NM_152739
HOXA9	hsa-miR-4282	93.2544	NM_152739
HOXA9	hsa-miR-5002-5p	93.0418	NM_152739
HOXA9	hsa-miR-670-3p	92.848	NM_152739
HOXA9	hsa-miR-548q	92.4885	NM_152739
HOXA9	hsa-miR-548g-5p	92.0342	NM_152739
HOXA9	hsa-miR-548x-5p	92.0342	NM_152739
HOXA9	hsa-miR-548aj-5p	92.0342	NM_152739
HOXA9	hsa-miR-1297	91.7414	NM_152739
HOXA9	hsa-miR-3927-3p	91.4823	NM_152739
HOXA9	hsa-miR-1277-5p	90.14	NM_152739
HOXA9	hsa-miR-3124-3p	90.0511	NM_152739
HOXA9	hsa-miR-26a-5p	89.6428	NM_152739
HOXA9	hsa-miR-26b-5p	89.6428	NM_152739
HOXA9	hsa-miR-4443	89.0124	NM_152739
HOXA9	hsa-miR-622	88.9021	NM_152739
HOXA9	hsa-miR-12133	88.7137	NM_152739
HOXA9	hsa-miR-4762-5p	88.1829	NM_152739
HOXA9	hsa-miR-4672	87.894	NM_152739
HOXA9	hsa-miR-376a-2-5p	87.7492	NM_152739
HOXA9	hsa-miR-6826-3p	87.5273	NM_152739
HOXA9	hsa-miR-96-5p	87.1151	NM_152739
HOXA9	hsa-miR-1245b-5p	87.0024	NM_152739
HOXA9	hsa-miR-4470	86.8615	NM_152739
HOXA9	hsa-miR-4465	86.6388	NM_152739
HOXA9	hsa-miR-1271-5p	86.374	NM_152739
HOXA9	hsa-miR-338-5p	85.9998	NM_152739
HOXA9	hsa-miR-6842-5p	85.6142	NM_152739

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Motifs and transcription factors (TFs) regulating HOXA9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HOXA9	transfac_pro__M01122	ZNF219 (directAnnotation).
HOXA9	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
HOXA9	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."