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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HOPX

Summary for HOPX

Gene information	Gene symbol	HOPX
	Ensembl ID	ENSG00000171476
	Entrez ID	84525
	Gene name	HOP homeobox
	Synonyms	HOP\|LAGY\|NECC1\|OB1\|SMAP31
	Gene type	protein_coding
	UniProtAcc	Q9BPY8

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Dataset with differentially expressed gene: HOPX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.263208	3.71e-27
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.322051	8.88e-37
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	CD8+ T cells	0.388578	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	0.308594	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.48115	2.02e-04
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	0.26884	1.14e-18
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.344292	6.86e-20
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.666629	4.88e-31
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	0.335815	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	0.382867	1.94e-31
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD4+ T cells	-0.343348	3.57e-02
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	NK cells	-0.591077	1.35e-38
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD8+ T cells	-0.365516	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-0.614462	1.24e-12
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD4+ T cells	-0.876097	1.65e-06
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	0.561766	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	CD8+ T cells	-0.295121	2.05e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.649589	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.669751	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.32321	6.41e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.351035	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.397717	5.72e-04
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	NK cells	0.7452	2.45e-40
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	CD8+ T cells	-0.512243	0.00e+00

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Expression of HOPX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HOPX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HOPX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HOPX	hsa-miR-7159-5p	97.3903	NM_001145460
HOPX	hsa-miR-676-5p	96.6431	NM_001145460
HOPX	hsa-miR-421	95.589	NM_001145460
HOPX	hsa-miR-1252-5p	94.8909	NM_001145460
HOPX	hsa-miR-627-3p	92.4117	NM_001145459
HOPX	hsa-miR-3065-5p	91.0511	NM_001145460
HOPX	hsa-miR-4672	88.9922	NM_001145459
HOPX	hsa-miR-4469	87.6171	NM_001145459
HOPX	hsa-miR-7162-5p	86.7548	NM_001145459
HOPX	hsa-miR-516b-3p	86.7548	NM_001145459
HOPX	hsa-miR-516a-3p	86.7548	NM_001145459
HOPX	hsa-miR-876-3p	86.0146	NM_001145459
HOPX	hsa-miR-4306	85.1836	NM_001145460
HOPX	hsa-miR-4644	85.1836	NM_001145460
HOPX	hsa-miR-9500	84.7493	NM_001145459
HOPX	hsa-miR-4694-3p	81.5765	NM_001145459
HOPX	hsa-miR-185-5p	80.7384	NM_001145460
HOPX	hsa-miR-329-5p	80.4059	NM_001145459

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Motifs and transcription factors (TFs) regulating HOPX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HOPX	transfac_pro__M06104	ZNF16 (directAnnotation).
HOPX	transfac_pro__M05779	ZNF674 (directAnnotation).
HOPX	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
HOPX	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
HOPX	metacluster_52.10	GTF3C2; ZNF436 (directAnnotation).
HOPX	transfac_pro__M06257	ZNF616 (directAnnotation).
HOPX	metacluster_143.1	ZSCAN31 (directAnnotation).
HOPX	metacluster_22.11	NFE2 (directAnnotation).
HOPX	metacluster_97.2	GTF3A (inferredBy_Orthology).
HOPX	transfac_pro__M05751	ZNF141 (directAnnotation).
HOPX	transfac_pro__M06941	DDIT3 (directAnnotation).
HOPX	transfac_pro__M05590	ZNF772 (directAnnotation).
HOPX	transfac_pro__M06727	PRDM6 (directAnnotation).
HOPX	transfac_pro__M00687	NFYC (directAnnotation). NFYA (inferredBy_Orthology).
HOPX	c2h2_zfs__M0401	ZNF410 (inferredBy_Orthology).
HOPX	tfdimers__MD00074	SOX4; YY2 (directAnnotation).
HOPX	metacluster_27.8	SOX10; SOX9 (directAnnotation).
HOPX	transfac_pro__M06523	ZNF527 (directAnnotation).
HOPX	transfac_pro__M05572	ZFP91; ZFP91-CNTF (inferredBy_Orthology).
HOPX	jaspar__MA0056.2	MZF1 (directAnnotation).
HOPX	transfac_pro__M06405	ZNF329 (directAnnotation).
HOPX	swissregulon__mm__Nkx3-2	NKX3-2 (inferredBy_Orthology).
HOPX	cisbp__M00832	TBX1 (inferredBy_Orthology).
HOPX	metacluster_155.33	ZNF16; ZNF816 (directAnnotation).
HOPX	transfac_pro__M06217	ZNF169 (directAnnotation).
HOPX	transfac_pro__M06976	PBX4 (directAnnotation).
HOPX	metacluster_63.4	ZNF672 (directAnnotation).
HOPX	metacluster_155.32	HIC1; ZBTB18; ZBTB42 (directAnnotation). ZNF134; ZNF134; ZNF154; ZNF154; ZNF256; ZNF256; ZNF304; ZNF304; ZNF418; ZNF418; ZNF419; ZNF419; ZNF480; ZNF480; ZNF548; ZNF548; ZNF549; ZNF549; ZNF552; ZNF552; ZNF561; ZNF561; ZNF562; ZNF562; ZNF584; ZNF584; ZNF586; ZNF586; ZNF587B; ZNF587B; ZNF610; ZNF610; ZNF772; ZNF772; ZNF773; ZNF773; ZNF792; ZNF792; ZNF793; ZNF793; ZNF837; ZNF837 (inferredBy_Orthology).
HOPX	metacluster_44.5	NKX3-1 (inferredBy_Orthology).
HOPX	taipale_tf_pairs__RFX3_ETV7_NNNMGGAANNNNNTCCNNNRCAACN_CAP_repr	ETV7; RFX3 (directAnnotation).
HOPX	transfac_pro__M04858	THAP1 (directAnnotation).
HOPX	metacluster_26.7	MYNN; MYNN (directAnnotation).
HOPX	transfac_pro__M05610	YY2 (directAnnotation).
HOPX	metacluster_44.19	NKX3-1 (inferredBy_Orthology).
HOPX	metacluster_28.1	NKX2-1; NKX2-1; NKX2-1; NKX2-1; NKX2-2; NKX2-3; NKX2-3; NKX2-3; NKX2-3; NKX2-3; NKX2-3; NKX2-3; NKX2-4; NKX2-4; NKX2-4; NKX2-5; NKX2-5; NKX2-5; NKX2-5; NKX2-6; NKX2-8; NKX2-8; NKX2-8; NKX2-8 (directAnnotation). NKX2-6; NKX2-6; NKX2-6 (inferredBy_Orthology).
HOPX	transfac_pro__M06482	ZNF547 (directAnnotation).
HOPX	jaspar__MA1994.1	NKX2-1 (inferredBy_Orthology).
HOPX	transfac_pro__M01660	GABPA (directAnnotation).
HOPX	metacluster_44.4	NKX3-1 (inferredBy_Orthology).
HOPX	metacluster_155.29	ZNF2 (directAnnotation). ZNF2 (inferredBy_Orthology).
HOPX	metacluster_92.3	ZNF354A (directAnnotation). ZNF354B (inferredBy_Orthology).
HOPX	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
HOPX	metacluster_116.2	ELK3; ELK3; ETV4 (directAnnotation).
HOPX	transfac_pro__M05915	ZBTB20 (directAnnotation).
HOPX	taipale_tf_pairs__HOXD12_ELK3_RSCGGAAGTAATAAAN_CAP	ELK3; HOXD12 (directAnnotation).
HOPX	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
HOPX	taipale_tf_pairs__GCM2_TEF_RTRCGGGNNNNTTACGTAA_CAP_repr	GCM2; TEF (directAnnotation).
HOPX	transfac_pro__M06564	ZNF578 (directAnnotation).
HOPX	transfac_pro__M05760	ZNF648 (directAnnotation).
HOPX	tfdimers__MD00429	ARID3A; IKZF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."