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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HOOK3

Summary for HOOK3

Gene information	Gene symbol	HOOK3
	Ensembl ID	ENSG00000168172
	Entrez ID	84376
	Gene name	hook microtubule tethering protein 3
	Synonyms	HK3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HOOK3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.276151	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.274064	2.15e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.326557	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.466122	0.00e+00

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Expression of HOOK3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HOOK3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HOOK3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HOOK3	hsa-miR-3662	99.9662	NM_032410
HOOK3	hsa-miR-570-3p	99.9399	NM_032410
HOOK3	hsa-miR-3133	99.8071	NM_032410
HOOK3	hsa-miR-374c-5p	99.8028	NM_032410
HOOK3	hsa-miR-655-3p	99.8028	NM_032410
HOOK3	hsa-miR-3646	99.746	NM_032410
HOOK3	hsa-miR-5692a	99.7115	NM_032410
HOOK3	hsa-miR-524-5p	99.6954	NM_032410
HOOK3	hsa-miR-520d-5p	99.6954	NM_032410
HOOK3	hsa-miR-4735-5p	99.426	NM_032410
HOOK3	hsa-miR-4307	99.2981	NM_032410
HOOK3	hsa-miR-204-5p	98.9527	NM_032410
HOOK3	hsa-miR-211-5p	98.9527	NM_032410
HOOK3	hsa-miR-186-5p	98.8977	NM_032410
HOOK3	hsa-miR-548c-3p	98.7	NM_032410
HOOK3	hsa-miR-3613-3p	98.3276	NM_032410
HOOK3	hsa-miR-590-3p	98.3132	NM_032410
HOOK3	hsa-miR-4775	98.299	NM_032410
HOOK3	hsa-miR-153-5p	98.2225	NM_032410
HOOK3	hsa-miR-3163	98.0494	NM_032410
HOOK3	hsa-miR-6780a-5p	97.657	NM_032410
HOOK3	hsa-miR-33a-3p	97.6479	NM_032410
HOOK3	hsa-miR-1271-5p	97.596	NM_032410
HOOK3	hsa-miR-194-5p	97.5772	NM_032410
HOOK3	hsa-miR-12133	97.5646	NM_032410
HOOK3	hsa-miR-656-3p	97.3812	NM_032410
HOOK3	hsa-let-7b-3p	97.2538	NM_032410
HOOK3	hsa-let-7f-1-3p	97.2538	NM_032410
HOOK3	hsa-let-7a-3p	97.2538	NM_032410
HOOK3	hsa-miR-98-3p	97.2538	NM_032410
HOOK3	hsa-miR-96-5p	97.1822	NM_032410
HOOK3	hsa-miR-5696	97.1464	NM_032410
HOOK3	hsa-miR-12136	96.9792	NM_032410
HOOK3	hsa-miR-1252-3p	96.9058	NM_032410
HOOK3	hsa-miR-4668-5p	96.7522	NM_032410
HOOK3	hsa-miR-3689b-3p	96.3242	NM_032410
HOOK3	hsa-miR-6779-5p	96.3242	NM_032410
HOOK3	hsa-miR-3689c	96.3242	NM_032410
HOOK3	hsa-miR-3689a-3p	96.3242	NM_032410
HOOK3	hsa-miR-30b-3p	96.3242	NM_032410
HOOK3	hsa-miR-1273h-5p	96.3242	NM_032410
HOOK3	hsa-miR-182-5p	95.9967	NM_032410
HOOK3	hsa-miR-7152-5p	95.9672	NM_032410
HOOK3	hsa-miR-4803	95.9191	NM_032410
HOOK3	hsa-miR-3148	95.8997	NM_032410
HOOK3	hsa-miR-4476	95.6421	NM_032410
HOOK3	hsa-miR-6876-5p	95.6421	NM_032410
HOOK3	hsa-miR-548l	95.5517	NM_032410
HOOK3	hsa-miR-300	95.3279	NM_032410
HOOK3	hsa-miR-381-3p	95.3279	NM_032410

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Motifs and transcription factors (TFs) regulating HOOK3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HOOK3	metacluster_135.11	NR2C2 (directAnnotation).
HOOK3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
HOOK3	tfdimers__MD00038	TFAP2C (directAnnotation).
HOOK3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
HOOK3	metacluster_7.13	ZFX (directAnnotation).
HOOK3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
HOOK3	cisbp__M00968	MTF2 (directAnnotation).
HOOK3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
HOOK3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
HOOK3	cisbp__M00341	PAX6 (directAnnotation).
HOOK3	metacluster_198.3	ZFP64 (directAnnotation).
HOOK3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
HOOK3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
HOOK3	cisbp__M00788	ZFY (inferredBy_Orthology).
HOOK3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
HOOK3	metacluster_175.1	ZNF283 (directAnnotation).
HOOK3	hdpi__ZNF304	ZNF304 (directAnnotation).
HOOK3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
HOOK3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
HOOK3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
HOOK3	transfac_pro__M01199	TRIM28 (directAnnotation).
HOOK3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
HOOK3	metacluster_151.2	ZNF23 (directAnnotation).
HOOK3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
HOOK3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
HOOK3	transfac_pro__M03806	ZBTB7C (directAnnotation).
HOOK3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
HOOK3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
HOOK3	cisbp__M00249	WT1 (directAnnotation).
HOOK3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
HOOK3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
HOOK3	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
HOOK3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
HOOK3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
HOOK3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
HOOK3	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
HOOK3	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
HOOK3	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
HOOK3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
HOOK3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
HOOK3	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
HOOK3	transfac_pro__M01253	CNOT3 (directAnnotation).
HOOK3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
HOOK3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
HOOK3	jaspar__MA1721.1	ZNF93 (directAnnotation).
HOOK3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
HOOK3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
HOOK3	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
HOOK3	jaspar__MA1122.1	TFDP1 (directAnnotation).
HOOK3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."