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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HNRNPLL

Summary for HNRNPLL

Gene information	Gene symbol	HNRNPLL
	Ensembl ID	ENSG00000143889
	Entrez ID	92906
	Gene name	heterogeneous nuclear ribonucleoprotein L like
	Synonyms	HNRPLL
	Gene type	protein_coding
	UniProtAcc	Q8WVV9

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Dataset with differentially expressed gene: HNRNPLL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.453185	0.00e+00

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Expression of HNRNPLL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HNRNPLL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HNRNPLL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HNRNPLL	hsa-miR-3163	95.9219	NM_001142650
HNRNPLL	hsa-miR-570-3p	93.8687	NM_138394
HNRNPLL	hsa-miR-6505-5p	93.4871	NM_138394
HNRNPLL	hsa-miR-522-3p	93.3884	NM_138394
HNRNPLL	hsa-miR-224-3p	93.3884	NM_138394
HNRNPLL	hsa-miR-3065-5p	93.0528	NM_001142650
HNRNPLL	hsa-miR-1468-3p	92.5761	NM_001142650
HNRNPLL	hsa-miR-4708-3p	92.0315	NM_001142650
HNRNPLL	hsa-miR-302a-5p	90.085	NM_138394
HNRNPLL	hsa-miR-4424	90.0101	NM_138394
HNRNPLL	hsa-miR-6820-3p	89.6239	NM_138394
HNRNPLL	hsa-miR-3164	89.6239	NM_138394
HNRNPLL	hsa-miR-12132	89.2315	NM_138394
HNRNPLL	hsa-miR-4760-5p	88.9788	NM_138394
HNRNPLL	hsa-miR-4307	88.2428	NM_138394
HNRNPLL	hsa-miR-2054	88.0972	NM_138394
HNRNPLL	hsa-miR-1233-5p	86.9531	NM_138394
HNRNPLL	hsa-miR-6778-5p	86.9531	NM_138394
HNRNPLL	hsa-miR-8061	86.4565	NM_138394
HNRNPLL	hsa-miR-3646	86.4446	NM_001142650
HNRNPLL	hsa-miR-381-3p	86.2722	NM_138394
HNRNPLL	hsa-miR-300	86.2722	NM_138394
HNRNPLL	hsa-miR-5692a	86.1773	NM_138394
HNRNPLL	hsa-miR-3190-3p	83.7906	NM_138394
HNRNPLL	hsa-miR-20b-3p	82.7476	NM_138394
HNRNPLL	hsa-miR-196a-3p	82.7029	NM_001142650
HNRNPLL	hsa-miR-6503-3p	82.2296	NM_001142650
HNRNPLL	hsa-miR-3529-3p	80.5189	NM_138394

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Motifs and transcription factors (TFs) regulating HNRNPLL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HNRNPLL	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
HNRNPLL	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
HNRNPLL	hdpi__NRL	NRL (directAnnotation).
HNRNPLL	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
HNRNPLL	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
HNRNPLL	hdpi__RARA	RARA (directAnnotation).
HNRNPLL	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
HNRNPLL	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
HNRNPLL	transfac_pro__M04893	TAF1 (directAnnotation).
HNRNPLL	hdpi__FEZF2	FEZF2 (directAnnotation).
HNRNPLL	hocomoco__FEV_HUMAN.H11MO.0.B	FEV (directAnnotation).
HNRNPLL	hdpi__HIP2	UBE2K (directAnnotation).
HNRNPLL	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
HNRNPLL	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
HNRNPLL	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
HNRNPLL	hdpi__PDLIM5	PDLIM5 (directAnnotation).
HNRNPLL	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
HNRNPLL	hdpi__HTATIP2	HTATIP2 (directAnnotation).
HNRNPLL	transfac_pro__M04817	ZBTB33 (directAnnotation).
HNRNPLL	transfac_pro__M01199	TRIM28 (directAnnotation).
HNRNPLL	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
HNRNPLL	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
HNRNPLL	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
HNRNPLL	hdpi__OTUD4	OTUD4 (directAnnotation).
HNRNPLL	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
HNRNPLL	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
HNRNPLL	transfac_pro__M07436	WT1 (directAnnotation).
HNRNPLL	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."