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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HNRNPL

Summary for HNRNPL

Gene information	Gene symbol	HNRNPL
	Ensembl ID	ENSG00000282947
	Entrez ID	3191
	Gene name	heterogeneous nuclear ribonucleoprotein L
	Synonyms	HNRPL
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HNRNPL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.337608	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.4522	7.53e-31
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	-0.252428	6.51e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.334149	1.68e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.256211	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.490925	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.531802	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.31866	1.11e-18

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Expression of HNRNPL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HNRNPL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HNRNPL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HNRNPL	hsa-miR-548az-5p	90.9502	NM_001533
HNRNPL	hsa-miR-548t-5p	90.9502	NM_001533
HNRNPL	hsa-miR-3148	88.7723	NM_001533
HNRNPL	hsa-miR-30c-1-3p	88.1897	NM_001005335
HNRNPL	hsa-miR-30c-2-3p	88.1897	NM_001005335
HNRNPL	hsa-miR-6788-5p	88.1897	NM_001005335
HNRNPL	hsa-miR-455-5p	88.0291	NM_001005335
HNRNPL	hsa-miR-450b-5p	86.8716	NM_001533
HNRNPL	hsa-miR-6731-5p	86.1411	NM_001005335
HNRNPL	hsa-miR-8085	86.1411	NM_001005335
HNRNPL	hsa-miR-6893-3p	83.0424	NM_001005335
HNRNPL	hsa-miR-370-3p	83.0424	NM_001005335
HNRNPL	hsa-miR-887-5p	82.8758	NM_001005335
HNRNPL	hsa-miR-3609	82.5723	NM_001533
HNRNPL	hsa-miR-548ah-5p	82.5723	NM_001533
HNRNPL	hsa-miR-6878-5p	81.4529	NM_001005335
HNRNPL	hsa-miR-590-3p	81.2609	NM_001533

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Motifs and transcription factors (TFs) regulating HNRNPL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HNRNPL	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
HNRNPL	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
HNRNPL	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
HNRNPL	transfac_pro__M00652	NRF1 (directAnnotation).
HNRNPL	metacluster_141.4	GLIS2 (directAnnotation).
HNRNPL	hocomoco__SOX9_HUMAN.H11MO.1.B	SOX9 (directAnnotation).
HNRNPL	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
HNRNPL	tfdimers__MD00470	TP53 (directAnnotation).
HNRNPL	tfdimers__MD00454	ARID3A; PAX4 (directAnnotation).
HNRNPL	transfac_pro__M04810	USF2 (directAnnotation).
HNRNPL	transfac_pro__M06557	ZNF418 (directAnnotation).
HNRNPL	jaspar__MA1125.1	ZNF384 (directAnnotation).
HNRNPL	cisbp__M00839	FOXP1 (directAnnotation).
HNRNPL	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
HNRNPL	kznf__ZNF182_Imbeault2017_OM_RCADE	ZNF182 (directAnnotation).
HNRNPL	tfdimers__MD00255	PAX7; PITX3 (directAnnotation).
HNRNPL	tfdimers__MD00163	RARA; RARB; RARG; RXRA; RXRB; RXRG; THRA; THRB (directAnnotation).
HNRNPL	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
HNRNPL	cisbp__M00249	WT1 (directAnnotation).
HNRNPL	transfac_pro__M02861	GATA6 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HNRNPL	"Copper"	DB09130	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."