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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HNMT

Summary for HNMT

Gene information	Gene symbol	HNMT
	Ensembl ID	ENSG00000150540
	Entrez ID	3176
	Gene name	histamine N-methyltransferase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P50135

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Dataset with differentially expressed gene: HNMT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.302434	2.98e-29
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.627476	0.00e+00

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Expression of HNMT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HNMT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HNMT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HNMT	hsa-miR-186-5p	99.0742	NM_006895
HNMT	hsa-miR-4775	97.0753	NM_006895
HNMT	hsa-miR-433-3p	96.9974	NM_001024075
HNMT	hsa-miR-3065-5p	95.6616	NM_001024075
HNMT	hsa-miR-126-5p	95.1045	NM_006895
HNMT	hsa-miR-7159-5p	93.882	NM_001024075
HNMT	hsa-miR-494-3p	93.0948	NM_006895
HNMT	hsa-miR-590-3p	93.0771	NM_006895
HNMT	hsa-miR-374a-5p	92.8681	NM_006895
HNMT	hsa-miR-374b-5p	92.2341	NM_006895
HNMT	hsa-miR-944	90.8045	NM_006895
HNMT	hsa-miR-4795-3p	90.6136	NM_006895
HNMT	hsa-miR-374c-3p	88.6763	NM_006895
HNMT	hsa-miR-6508-5p	88.5573	NM_006895
HNMT	hsa-miR-8067	88.0537	NM_006895
HNMT	hsa-miR-3917	88.0267	NM_001024074
HNMT	hsa-miR-3168	87.8635	NM_006895
HNMT	hsa-miR-5583-3p	86.9242	NM_006895
HNMT	hsa-miR-3190-5p	86.7268	NM_001024074
HNMT	hsa-miR-4780	85.5231	NM_006895
HNMT	hsa-miR-3688-3p	85.4926	NM_006895
HNMT	hsa-miR-1255a	85.2281	NM_006895
HNMT	hsa-miR-1255b-5p	85.2281	NM_006895
HNMT	hsa-miR-6873-3p	85.0369	NM_006895
HNMT	hsa-miR-8070	84.0698	NM_006895
HNMT	hsa-miR-1252-3p	83.8506	NM_006895
HNMT	hsa-miR-1206	83.6039	NM_001024075
HNMT	hsa-miR-6833-3p	83.4654	NM_006895
HNMT	hsa-miR-124-5p	83.0338	NM_006895
HNMT	hsa-miR-676-5p	82.8336	NM_001024075
HNMT	hsa-miR-6770-5p	82.8168	NM_006895
HNMT	hsa-miR-3615	81.8789	NM_001024074
HNMT	hsa-miR-579-3p	81.8515	NM_006895
HNMT	hsa-miR-664b-3p	81.8515	NM_006895
HNMT	hsa-miR-4517	81.7927	NM_006895
HNMT	hsa-miR-3064-5p	81.6159	NM_006895
HNMT	hsa-miR-6504-5p	81.6159	NM_006895
HNMT	hsa-miR-3085-3p	81.6159	NM_006895
HNMT	hsa-miR-4519	81.2286	NM_001024075
HNMT	hsa-miR-4768-5p	80.6811	NM_006895
HNMT	hsa-miR-323a-3p	80.4598	NM_001024075
HNMT	hsa-miR-1252-5p	80.031	NM_006895

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Motifs and transcription factors (TFs) regulating HNMT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HNMT	transfac_pro__M05418	ZNF521 (directAnnotation).
HNMT	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
HNMT	metacluster_22.29	NFE2 (directAnnotation).
HNMT	metacluster_22.17	NFE2 (directAnnotation).
HNMT	tfdimers__MD00208	IRF1; LTF (directAnnotation).
HNMT	metacluster_22.25	NFE2L2 (directAnnotation).
HNMT	metacluster_22.18	BACH2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HNMT	"Amodiaquine"	DB00613	small molecule
HNMT	"Harmaline"	DB13875	small molecule
HNMT	"Metoprine"	DB04655	small molecule
HNMT	"S-adenosyl-L-homocysteine"	DB01752	small molecule
HNMT	"SKF-91488"	DB07106	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."