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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HNF4A

Summary for HNF4A

Gene information	Gene symbol	HNF4A
	Ensembl ID	ENSG00000101076
	Entrez ID	3172
	Gene name	hepatocyte nuclear factor 4 alpha
	Synonyms	HNF4\|MODY\|MODY1\|NR2A1\|TCF14
	Gene type	protein_coding
	UniProtAcc	P41235

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Dataset with differentially expressed gene: HNF4A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.683952	0.00e+00

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Expression of HNF4A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HNF4A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HNF4A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HNF4A	hsa-miR-92a-2-5p	97.3944	NM_001030003
HNF4A	hsa-miR-8063	95.7289	NM_001287184
HNF4A	hsa-miR-3059-3p	93.8935	NM_000457
HNF4A	hsa-miR-34a-5p	93.4584	NM_000457
HNF4A	hsa-miR-449a	93.4584	NM_000457
HNF4A	hsa-miR-4739	93.4532	NM_000457
HNF4A	hsa-miR-4756-5p	93.4532	NM_000457
HNF4A	hsa-miR-1321	93.4532	NM_000457
HNF4A	hsa-miR-765	92.2637	NM_001030003
HNF4A	hsa-miR-449b-5p	92.0855	NM_000457
HNF4A	hsa-miR-34c-5p	92.0855	NM_000457
HNF4A	hsa-miR-4316	91.7954	NM_001287184
HNF4A	hsa-miR-4787-3p	89.4476	NM_001030003
HNF4A	hsa-miR-548at-5p	88.2329	NM_001030003
HNF4A	hsa-miR-3972	88.1978	NM_001287184
HNF4A	hsa-miR-1202	88.1978	NM_001287184
HNF4A	hsa-miR-11181-3p	86.4957	NM_001030003
HNF4A	hsa-miR-7977	85.1048	NM_001030003
HNF4A	hsa-miR-629-5p	84.9612	NM_001030003
HNF4A	hsa-miR-5693	84.5007	NM_001030003
HNF4A	hsa-miR-6846-5p	83.7467	NM_001030003
HNF4A	hsa-miR-6839-3p	82.4899	NM_001030003
HNF4A	hsa-miR-7106-5p	82.1671	NM_000457
HNF4A	hsa-miR-4516	81.1877	NM_001030003

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Motifs and transcription factors (TFs) regulating HNF4A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HNF4A	"AVI-4557"	DB05447	small molecule
HNF4A	"Lauric acid"	DB03017	small molecule
HNF4A	"Myristic acid"	DB08231	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."