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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HMOX1

Summary for HMOX1

Gene information	Gene symbol	HMOX1
	Ensembl ID	ENSG00000100292
	Entrez ID	3162
	Gene name	heme oxygenase 1
	Synonyms	bK286B10\|HO-1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HMOX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.357671	2.29e-26
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-2.24705	0.00e+00
GSE212217	patients	Peripheral blood mononuclear cells	Endometrial cancer	Epigenetic MMRd endometrial carcinoma	Immunotherapy	pembrolizumab	pre	Mono/Macro	-0.288158	8.15e-19
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.994316	2.16e-04
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.301254	5.18e-24
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.17079	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.93925	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.538932	6.93e-36
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.705468	3.36e-16

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Expression of HMOX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HMOX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
HMOX1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating HMOX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HMOX1	hsa-miR-377-3p	96.3999	NM_002133
HMOX1	hsa-miR-5003-5p	88.4515	NM_002133
HMOX1	hsa-miR-4795-3p	87.3337	NM_002133
HMOX1	hsa-miR-520a-5p	84.6371	NM_002133
HMOX1	hsa-miR-525-5p	84.6371	NM_002133
HMOX1	hsa-miR-1291	82.2784	NM_002133
HMOX1	hsa-miR-873-5p	80.0058	NM_002133

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Motifs and transcription factors (TFs) regulating HMOX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HMOX1	metacluster_22.19	NFE2 (directAnnotation).
HMOX1	metacluster_22.18	BACH2 (inferredBy_Orthology).
HMOX1	metacluster_22.37	BACH1 (directAnnotation).
HMOX1	metacluster_22.36	BACH2 (directAnnotation).
HMOX1	metacluster_22.34	BACH2 (directAnnotation).
HMOX1	metacluster_22.20	MAFG (directAnnotation).
HMOX1	metacluster_22.35	MAFK (directAnnotation).
HMOX1	metacluster_22.16	BACH2 (directAnnotation).
HMOX1	metacluster_22.11	NFE2 (directAnnotation).
HMOX1	metacluster_22.13	MAFK (inferredBy_Orthology).
HMOX1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
HMOX1	metacluster_22.33	MAFK (inferredBy_Orthology).
HMOX1	metacluster_22.32	NFE2L2 (directAnnotation).
HMOX1	metacluster_22.39	NFE2L2 (directAnnotation).
HMOX1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
HMOX1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
HMOX1	metacluster_22.17	NFE2 (directAnnotation).
HMOX1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
HMOX1	transfac_pro__M00514	ATF4 (directAnnotation).
HMOX1	tfdimers__MD00012	ETS1; YY1 (directAnnotation).
HMOX1	dbtfbs__NCOA3_MCF-7_ENCSR573OJP_merged_N2	NCOA3 (directAnnotation).
HMOX1	transfac_pro__M05423	RREB1 (directAnnotation).
HMOX1	tfdimers__MD00349	GABPA; YY2 (directAnnotation).
HMOX1	tfdimers__MD00515	ARID3A; KLF4 (directAnnotation).
HMOX1	transfac_pro__M02280	FOS; JUN (directAnnotation).
HMOX1	transfac_pro__M04699	MAFK (directAnnotation).
HMOX1	metacluster_137.5	FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; JUN; JUNB; JUNB; JUND; JUND (directAnnotation). JUN (inferredBy_Orthology).
HMOX1	transfac_pro__M06130	ZNF254 (directAnnotation).
HMOX1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
HMOX1	swissregulon__hs__HSF2	HSF2 (directAnnotation).
HMOX1	metacluster_167.8	ZKSCAN5; ZKSCAN5 (directAnnotation).
HMOX1	metacluster_57.5	ZKSCAN5 (directAnnotation).
HMOX1	metacluster_22.29	NFE2 (directAnnotation).
HMOX1	metacluster_22.25	NFE2L2 (directAnnotation).
HMOX1	metacluster_22.14	BACH1 (inferredBy_Orthology).
HMOX1	transfac_pro__M04949	GATA2 (directAnnotation).
HMOX1	metacluster_21.4	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
HMOX1	metacluster_22.15	BACH1 (directAnnotation).
HMOX1	metacluster_27.21	CNOT6; ZNF112 (directAnnotation). ZNF112 (inferredBy_Orthology).
HMOX1	transfac_pro__M01267	FOSL1 (directAnnotation).
HMOX1	tfdimers__MD00405	HLTF; IRF1 (directAnnotation).
HMOX1	tfdimers__MD00245	GABPA; GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
HMOX1	transfac_pro__M04765	PAX5 (directAnnotation).
HMOX1	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
HMOX1	metacluster_22.1	MAFF (inferredBy_Orthology).
HMOX1	metacluster_22.2	MAFK (directAnnotation).
HMOX1	transfac_pro__M03541	JUN (directAnnotation).
HMOX1	transfac_pro__M02095	FOSL1 (directAnnotation).
HMOX1	taipale_tf_pairs__HOXB13_ELK1_RSMGGAARTNNTAAAN_CAP	ELK1; HOXB13 (directAnnotation).
HMOX1	transfac_pro__M03870	FOSL2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HMOX1	"1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone"	DB07342	small molecule
HMOX1	"1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE"	DB06914	small molecule
HMOX1	"12-Phenylheme"	DB02468	small molecule
HMOX1	"2-Phenylheme"	DB03906	small molecule
HMOX1	"Biliverdine IX Alpha"	DB02073	small molecule
HMOX1	"Formic acid"	DB01942	small molecule
HMOX1	"NADH"	DB00157	small molecule
HMOX1	"Stannsoporfin"	DB04912	small molecule
HMOX1	"Verdoheme"	DB04803	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."