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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HMGCR

Summary for HMGCR

Gene information	Gene symbol	HMGCR
	Ensembl ID	ENSG00000113161
	Entrez ID	3156
	Gene name	3-hydroxy-3-methylglutaryl-CoA reductase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P04035

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Dataset with differentially expressed gene: HMGCR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.317288	1.21e-29

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Expression of HMGCR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HMGCR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
HMGCR	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating HMGCR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HMGCR	hsa-miR-4666a-3p	97.0682	NM_000859
HMGCR	hsa-let-7c-3p	95.4099	NM_000859
HMGCR	hsa-let-7b-3p	95.089	NM_000859
HMGCR	hsa-miR-98-3p	95.089	NM_000859
HMGCR	hsa-let-7a-3p	95.089	NM_000859
HMGCR	hsa-let-7f-1-3p	95.089	NM_000859
HMGCR	hsa-miR-1305	94.8673	NM_000859
HMGCR	hsa-miR-9985	92.6941	NM_000859
HMGCR	hsa-miR-27a-3p	92.6941	NM_000859
HMGCR	hsa-miR-27b-3p	92.6941	NM_000859
HMGCR	hsa-miR-513a-5p	92.6941	NM_000859
HMGCR	hsa-miR-146a-3p	92.2473	NM_000859
HMGCR	hsa-miR-4540	91.8557	NM_000859
HMGCR	hsa-miR-493-5p	91.6854	NM_000859
HMGCR	hsa-miR-6859-3p	91.2613	NM_000859
HMGCR	hsa-miR-6875-3p	90.2953	NM_000859
HMGCR	hsa-miR-7844-5p	90.2805	NM_000859
HMGCR	hsa-miR-664a-5p	89.995	NM_000859
HMGCR	hsa-miR-4794	89.995	NM_000859
HMGCR	hsa-miR-5690	89.5128	NM_000859
HMGCR	hsa-miR-4503	89.4429	NM_000859
HMGCR	hsa-miR-4704-3p	88.4681	NM_000859
HMGCR	hsa-miR-20b-3p	87.2748	NM_000859
HMGCR	hsa-miR-1323	86.7144	NM_000859
HMGCR	hsa-miR-653-3p	86.4331	NM_000859
HMGCR	hsa-miR-623	86.1184	NM_000859
HMGCR	hsa-miR-450a-1-3p	86.0452	NM_000859
HMGCR	hsa-miR-3690	85.3055	NM_000859
HMGCR	hsa-miR-374c-5p	84.4072	NM_000859
HMGCR	hsa-miR-655-3p	84.4072	NM_000859
HMGCR	hsa-miR-3065-3p	83.5182	NM_000859
HMGCR	hsa-miR-4778-5p	82.7095	NM_000859
HMGCR	hsa-miR-3133	82.211	NM_000859
HMGCR	hsa-miR-548o-3p	81.163	NM_000859
HMGCR	hsa-miR-6515-3p	81.0351	NM_000859
HMGCR	hsa-miR-760	80.4719	NM_000859
HMGCR	hsa-miR-8063	80.2095	NM_000859

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Motifs and transcription factors (TFs) regulating HMGCR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HMGCR	metacluster_135.11	NR2C2 (directAnnotation).
HMGCR	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
HMGCR	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
HMGCR	metacluster_7.13	ZFX (directAnnotation).
HMGCR	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
HMGCR	cisbp__M00968	MTF2 (directAnnotation).
HMGCR	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
HMGCR	metacluster_160.20	JUND; PRDM15 (directAnnotation).
HMGCR	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
HMGCR	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
HMGCR	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
HMGCR	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
HMGCR	cisbp__M00788	ZFY (inferredBy_Orthology).
HMGCR	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
HMGCR	metacluster_175.1	ZNF283 (directAnnotation).
HMGCR	hdpi__ZNF304	ZNF304 (directAnnotation).
HMGCR	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
HMGCR	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
HMGCR	transfac_pro__M01199	TRIM28 (directAnnotation).
HMGCR	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
HMGCR	metacluster_151.2	ZNF23 (directAnnotation).
HMGCR	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
HMGCR	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
HMGCR	transfac_pro__M03806	ZBTB7C (directAnnotation).
HMGCR	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HMGCR	"(S)-Hmg-Coa"	DB03169	small molecule
HMGCR	"1,4-Dithiothreitol"	DB04447	small molecule
HMGCR	"Atorvastatin"	DB01076	small molecule
HMGCR	"Cannabidiol"	DB09061	small molecule
HMGCR	"Cerivastatin"	DB00439	small molecule
HMGCR	"Coenzyme A"	DB01992	small molecule
HMGCR	"Fluvastatin"	DB01095	small molecule
HMGCR	"Lovastatin"	DB00227	small molecule
HMGCR	"Medical Cannabis"	DB14009	biotech
HMGCR	"Meglutol"	DB04377	small molecule
HMGCR	"Mevastatin"	DB06693	small molecule
HMGCR	"Nabiximols"	DB14011	small molecule
HMGCR	"NADH"	DB00157	small molecule
HMGCR	"Nicotinamide adenine dinucleotide phosphate"	DB03461	small molecule
HMGCR	"Pitavastatin"	DB08860	small molecule
HMGCR	"Pravastatin"	DB00175	small molecule
HMGCR	"Rosuvastatin"	DB01098	small molecule
HMGCR	"Simvastatin"	DB00641	small molecule
HMGCR	"TAK-475"	DB05317	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."