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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HLTF

Summary for HLTF

Gene information	Gene symbol	HLTF
	Ensembl ID	ENSG00000071794
	Entrez ID	6596
	Gene name	helicase like transcription factor
	Synonyms	HIP116A\|HLTF1\|RNF80\|SMARCA3\|SNF2L3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HLTF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.386066	7.64e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.358085	0.00e+00

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Expression of HLTF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HLTF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HLTF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HLTF	hsa-miR-512-5p	97.4711	NM_001318934
HLTF	hsa-miR-340-5p	96.8033	NM_001318934
HLTF	hsa-miR-4724-3p	96.2888	NM_139048
HLTF	hsa-miR-3163	95.9939	NM_001318934
HLTF	hsa-miR-548l	94.9125	NM_001318934
HLTF	hsa-miR-511-5p	94.9025	NM_139048
HLTF	hsa-miR-548at-5p	94.4393	NM_001318934
HLTF	hsa-miR-4799-5p	94.3846	NM_001318934
HLTF	hsa-miR-4742-3p	94.1401	NM_001318934
HLTF	hsa-miR-6848-3p	94.0973	NM_001318934
HLTF	hsa-miR-6843-3p	94.0973	NM_001318934
HLTF	hsa-miR-5582-3p	93.957	NM_001318934
HLTF	hsa-miR-137-3p	93.4617	NM_001318934
HLTF	hsa-miR-6830-3p	91.2315	NM_139048
HLTF	hsa-miR-574-5p	89.651	NM_001318934
HLTF	hsa-miR-3148	89.3761	NM_001318934
HLTF	hsa-miR-8068	88.659	NM_139048
HLTF	hsa-miR-4668-3p	88.3628	NM_001318934
HLTF	hsa-miR-548ar-5p	87.6972	NM_139048
HLTF	hsa-miR-559	87.6972	NM_139048
HLTF	hsa-miR-548c-5p	87.6972	NM_139048
HLTF	hsa-miR-548ap-5p	87.6972	NM_139048
HLTF	hsa-miR-548ak	87.6972	NM_139048
HLTF	hsa-miR-548w	87.6972	NM_139048
HLTF	hsa-miR-548a-5p	87.6972	NM_139048
HLTF	hsa-miR-548d-5p	87.6972	NM_139048
HLTF	hsa-miR-548as-5p	87.6972	NM_139048
HLTF	hsa-miR-548h-5p	87.6972	NM_139048
HLTF	hsa-miR-548ay-5p	87.6972	NM_139048
HLTF	hsa-miR-548ab	87.6972	NM_139048
HLTF	hsa-miR-548b-5p	87.6972	NM_139048
HLTF	hsa-miR-548i	87.6972	NM_139048
HLTF	hsa-miR-548bb-5p	87.6972	NM_139048
HLTF	hsa-miR-548aq-5p	87.6972	NM_139048
HLTF	hsa-miR-548ad-5p	87.6972	NM_139048
HLTF	hsa-miR-548am-5p	87.6972	NM_139048
HLTF	hsa-miR-548y	87.6972	NM_139048
HLTF	hsa-miR-548au-5p	87.6972	NM_139048
HLTF	hsa-miR-548o-5p	87.6972	NM_139048
HLTF	hsa-miR-548ae-5p	87.6972	NM_139048
HLTF	hsa-miR-548j-5p	87.6972	NM_139048
HLTF	hsa-miR-4476	87.6346	NM_001318935
HLTF	hsa-miR-6876-5p	87.6346	NM_001318935
HLTF	hsa-miR-6844	87.6338	NM_139048
HLTF	hsa-miR-8065	87.6192	NM_001318934
HLTF	hsa-miR-548n	87.174	NM_001318934
HLTF	hsa-miR-6837-3p	86.83	NM_001318934
HLTF	hsa-miR-204-5p	86.8049	NM_139048
HLTF	hsa-miR-211-5p	86.8049	NM_139048
HLTF	hsa-miR-548ar-3p	85.2303	NM_001318934

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Motifs and transcription factors (TFs) regulating HLTF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HLTF	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
HLTF	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
HLTF	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
HLTF	transfac_pro__M01298	MECP2 (directAnnotation).
HLTF	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
HLTF	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
HLTF	transfac_pro__M02913	SP140 (inferredBy_Orthology).
HLTF	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."