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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: HIP1

Summary for HIP1

Gene informationGene symbol

HIP1

Ensembl ID

ENSG00000127946

Entrez ID

3092

Gene namehuntingtin interacting protein 1
SynonymsILWEQ
Gene typeprotein_coding
UniProtAcc

O00291


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Dataset with differentially expressed gene: HIP1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.2612852.96e-12

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Expression of HIP1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to HIP1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HIP1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
HIP1hsa-miR-808599.2839NM_001243198
HIP1hsa-miR-6731-5p99.2839NM_001243198
HIP1hsa-miR-524-5p94.7881NM_001243198
HIP1hsa-miR-520d-5p94.7881NM_001243198
HIP1hsa-miR-4646-3p93.7677NM_001243198
HIP1hsa-miR-450093.2395NM_001243198
HIP1hsa-miR-6791-5p93.1362NM_001243198
HIP1hsa-miR-429293.1362NM_001243198
HIP1hsa-miR-544b93.0058NM_001243198
HIP1hsa-miR-4731-5p92.7208NM_001243198
HIP1hsa-let-7b-3p92.4763NM_001243198
HIP1hsa-let-7a-3p92.4763NM_001243198
HIP1hsa-miR-98-3p92.4763NM_001243198
HIP1hsa-let-7f-1-3p92.4763NM_001243198
HIP1hsa-miR-4433b-5p92.3519NM_001243198
HIP1hsa-let-7i-5p90.2088NM_001243198
HIP1hsa-let-7e-5p90.2088NM_001243198
HIP1hsa-miR-98-5p90.2088NM_001243198
HIP1hsa-let-7a-5p90.2088NM_001243198
HIP1hsa-let-7c-5p90.2088NM_001243198
HIP1hsa-let-7f-5p90.2088NM_001243198
HIP1hsa-let-7b-5p90.2088NM_001243198
HIP1hsa-let-7g-5p90.2088NM_001243198
HIP1hsa-miR-3622a-3p89.9663NM_001243198
HIP1hsa-miR-3622b-3p89.9663NM_001243198
HIP1hsa-miR-302e89.9641NM_001243198
HIP1hsa-miR-30c-2-3p89.8763NM_001243198
HIP1hsa-miR-6788-5p89.8763NM_001243198
HIP1hsa-miR-30c-1-3p89.8763NM_001243198
HIP1hsa-miR-445889.7479NM_001243198
HIP1hsa-let-7d-5p89.7479NM_001243198
HIP1hsa-miR-548n89.7074NM_001243198
HIP1hsa-miR-7162-3p88.1084NM_001243198
HIP1hsa-miR-6515-5p88.014NM_001243198
HIP1hsa-miR-444387.4375NM_001243198
HIP1hsa-miR-7110-5p86.5802NM_001243198
HIP1hsa-miR-619-5p85.6527NM_001243198
HIP1hsa-miR-570-3p85.4488NM_001243198
HIP1hsa-miR-6730-5p85.2717NM_001243198
HIP1hsa-miR-444784.5957NM_001243198
HIP1hsa-miR-6842-5p84.1804NM_001243198
HIP1hsa-miR-211383.6471NM_001243198
HIP1hsa-miR-6878-5p83.3429NM_001243198
HIP1hsa-miR-19a-3p83.262NM_001243198
HIP1hsa-miR-19b-3p83.262NM_001243198
HIP1hsa-miR-216a-3p83.1112NM_001243198
HIP1hsa-miR-128-3p83.1112NM_001243198
HIP1hsa-miR-4747-5p82.9317NM_001243198
HIP1hsa-miR-5196-5p82.9317NM_001243198
HIP1hsa-miR-520a-5p82.2551NM_001243198
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Motifs and transcription factors (TFs) regulating HIP1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
HIP1jaspar__MA0079.5SP1 (directAnnotation).
HIP1kznf__KLF1_Barrera2016.2_PBMKLF1 (directAnnotation).
HIP1transfac_pro__M01253CNOT3 (directAnnotation).
HIP1transfac_pro__M04817ZBTB33 (directAnnotation).
HIP1cisbp__M07938E2F1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."