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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HIF3A

Summary for HIF3A

Gene information	Gene symbol	HIF3A
	Ensembl ID	ENSG00000124440
	Entrez ID	64344
	Gene name	hypoxia inducible factor 3 subunit alpha
	Synonyms	bHLHe17\|IPAS\|MOP7\|PASD7
	Gene type	protein_coding
	UniProtAcc	Q9Y2N7

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Dataset with differentially expressed gene: HIF3A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.445902	2.18e-02

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Expression of HIF3A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HIF3A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HIF3A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HIF3A	hsa-miR-29b-3p	97.4839	NM_022462
HIF3A	hsa-miR-29a-3p	97.4839	NM_022462
HIF3A	hsa-miR-29c-3p	97.4839	NM_022462
HIF3A	hsa-miR-3613-3p	94.4884	NM_022462
HIF3A	hsa-miR-6847-5p	92.8131	NM_022462
HIF3A	hsa-miR-4478	92.0631	NM_022462
HIF3A	hsa-miR-5682	91.4038	NM_022462
HIF3A	hsa-miR-6742-5p	90.662	NM_022462
HIF3A	hsa-miR-4712-3p	89.297	NM_152796
HIF3A	hsa-miR-6079	88.4668	NM_022462
HIF3A	hsa-miR-3125	88.3105	NM_022462
HIF3A	hsa-miR-485-5p	88.1977	NM_022462
HIF3A	hsa-miR-6884-5p	88.1977	NM_022462
HIF3A	hsa-miR-6128	87.9332	NM_022462
HIF3A	hsa-miR-637	87.313	NM_022462
HIF3A	hsa-miR-3916	87.1778	NM_022462
HIF3A	hsa-miR-6859-5p	87.1778	NM_022462
HIF3A	hsa-miR-1283	86.9881	NM_152796
HIF3A	hsa-miR-3976	85.981	NM_022462
HIF3A	hsa-miR-4443	85.9755	NM_022462
HIF3A	hsa-miR-4316	85.6226	NM_022462
HIF3A	hsa-miR-616-5p	85.5836	NM_022462
HIF3A	hsa-miR-373-5p	85.5836	NM_022462
HIF3A	hsa-miR-371b-5p	85.5836	NM_022462
HIF3A	hsa-miR-361-3p	85.5121	NM_022462
HIF3A	hsa-miR-655-5p	85.4937	NM_022462
HIF3A	hsa-miR-3156-5p	85.443	NM_022462
HIF3A	hsa-miR-1200	85.0626	NM_022462
HIF3A	hsa-miR-1914-5p	84.7765	NM_022462
HIF3A	hsa-miR-548bb-3p	84.3311	NM_022462
HIF3A	hsa-miR-548z	84.3311	NM_022462
HIF3A	hsa-miR-548ac	84.3311	NM_022462
HIF3A	hsa-miR-548d-3p	84.3311	NM_022462
HIF3A	hsa-miR-548h-3p	84.3311	NM_022462
HIF3A	hsa-miR-4500	84.1888	NM_022462
HIF3A	hsa-miR-5008-5p	83.4696	NM_022462
HIF3A	hsa-miR-2114-3p	83.1106	NM_022462
HIF3A	hsa-miR-3185	82.5052	NM_022462
HIF3A	hsa-miR-6823-3p	81.5765	NM_022462
HIF3A	hsa-miR-6508-5p	81.4443	NM_022462
HIF3A	hsa-miR-4324	81.1517	NM_022462
HIF3A	hsa-miR-3929	80.6351	NM_022462
HIF3A	hsa-miR-4777-5p	80.4568	NM_022462

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Motifs and transcription factors (TFs) regulating HIF3A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."