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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: HIC1

Summary for HIC1

Gene information	Gene symbol	HIC1
	Ensembl ID	ENSG00000177374
	Entrez ID	3090
	Gene name	HIC ZBTB transcriptional repressor 1
	Synonyms	ZBTB29\|ZNF901
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HIC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.277732	3.50e-14

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Expression of HIC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HIC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HIC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HIC1	hsa-miR-144-5p	93.5207	NM_001098202
HIC1	hsa-miR-19a-3p	93.0811	NM_001098202
HIC1	hsa-miR-19b-3p	93.0811	NM_001098202
HIC1	hsa-miR-128-3p	92.719	NM_001098202
HIC1	hsa-miR-216a-3p	92.719	NM_001098202
HIC1	hsa-miR-6077	91.1703	NM_001098202
HIC1	hsa-miR-27b-3p	91.1653	NM_001098202
HIC1	hsa-miR-27a-3p	91.1653	NM_001098202
HIC1	hsa-miR-9985	91.1653	NM_001098202
HIC1	hsa-miR-5591-5p	90.7658	NM_001098202
HIC1	hsa-miR-4300	90.7658	NM_001098202
HIC1	hsa-miR-3681-3p	90.2557	NM_001098202
HIC1	hsa-miR-920	90.1323	NM_001098202
HIC1	hsa-miR-6726-5p	90.1323	NM_001098202
HIC1	hsa-miR-3202	88.6564	NM_001098202
HIC1	hsa-miR-3177-5p	88.4229	NM_001098202
HIC1	hsa-miR-3622a-5p	86.9143	NM_001098202
HIC1	hsa-let-7f-1-3p	84.1462	NM_001098202
HIC1	hsa-let-7b-3p	84.1462	NM_001098202
HIC1	hsa-let-7a-3p	84.1462	NM_001098202
HIC1	hsa-miR-98-3p	84.1462	NM_001098202
HIC1	hsa-miR-137-3p	83.9432	NM_001098202
HIC1	hsa-miR-1227-3p	80.5117	NM_001098202

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Motifs and transcription factors (TFs) regulating HIC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HIC1	metacluster_22.37	BACH1 (directAnnotation).
HIC1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
HIC1	tfdimers__MD00276	IRF1; STAT6 (directAnnotation).
HIC1	metacluster_111.5	E4F1; E4F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
HIC1	metacluster_24.1	down	Mono/Macro	GSE164551	NA
HIC1	tfdimers__MD00343	down	Mono/Macro	GSE164551	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."