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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HHIP

Summary for HHIP

Gene information	Gene symbol	HHIP
	Ensembl ID	ENSG00000164161
	Entrez ID	64399
	Gene name	hedgehog interacting protein
	Synonyms	FLJ20992\|HIP
	Gene type	protein_coding
	UniProtAcc	Q96QV1

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Dataset with differentially expressed gene: HHIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.268178	3.50e-21
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.345573	1.44e-20
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.325422	5.68e-16

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Expression of HHIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HHIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HHIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HHIP	hsa-miR-3163	99.9953	NM_022475
HHIP	hsa-miR-548c-3p	98.8967	NM_022475
HHIP	hsa-miR-365a-3p	97.6909	NM_022475
HHIP	hsa-miR-365b-3p	97.6909	NM_022475
HHIP	hsa-miR-1277-5p	97.1693	NM_022475
HHIP	hsa-miR-5011-5p	96.2798	NM_022475
HHIP	hsa-miR-4796-5p	95.8387	NM_022475
HHIP	hsa-miR-4699-5p	95.4463	NM_022475
HHIP	hsa-miR-340-5p	95.2905	NM_022475
HHIP	hsa-miR-548o-3p	95.1628	NM_022475
HHIP	hsa-miR-1299	94.9407	NM_022475
HHIP	hsa-miR-526b-5p	94.5814	NM_022475
HHIP	hsa-miR-1323	94.4311	NM_022475
HHIP	hsa-miR-618	93.9738	NM_022475
HHIP	hsa-miR-212-3p	93.4908	NM_022475
HHIP	hsa-miR-132-3p	93.4908	NM_022475
HHIP	hsa-miR-3686	92.9329	NM_022475
HHIP	hsa-miR-656-3p	92.0882	NM_022475
HHIP	hsa-miR-3941	91.8163	NM_022475
HHIP	hsa-miR-1324	90.9293	NM_022475
HHIP	hsa-miR-513a-5p	90.472	NM_022475
HHIP	hsa-miR-6759-3p	90.2942	NM_022475
HHIP	hsa-miR-8485	89.8041	NM_022475
HHIP	hsa-miR-4803	89.3789	NM_022475
HHIP	hsa-miR-1178-3p	88.1533	NM_022475
HHIP	hsa-miR-875-3p	87.5368	NM_022475
HHIP	hsa-miR-300	86.3314	NM_022475
HHIP	hsa-miR-1825	85.8455	NM_022475
HHIP	hsa-miR-4666a-3p	85.3171	NM_022475
HHIP	hsa-miR-4311	84.0304	NM_022475
HHIP	hsa-miR-8062	83.9743	NM_022475
HHIP	hsa-miR-3662	82.5381	NM_022475
HHIP	hsa-miR-1278	82.104	NM_022475

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Motifs and transcription factors (TFs) regulating HHIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HHIP	cisbp__M02645	ETS1 (directAnnotation).
HHIP	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
HHIP	transfac_pro__M04862	NRF1 (directAnnotation).
HHIP	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
HHIP	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
HHIP	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
HHIP	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
HHIP	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
HHIP	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
HHIP	cisbp__M00808	MYPOP (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."