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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HEG1

Summary for HEG1

Gene information	Gene symbol	HEG1
	Ensembl ID	ENSG00000173706
	Entrez ID	57493
	Gene name	heart development protein with EGF like domains 1
	Synonyms	HEG\|KIAA1237
	Gene type	protein_coding
	UniProtAcc	Q9ULI3

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Dataset with differentially expressed gene: HEG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.266151	2.66e-12
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.25778	5.86e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.606384	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.372938	5.34e-11

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Expression of HEG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HEG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HEG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HEG1	hsa-miR-519a-3p	98.336	NM_020733
HEG1	hsa-miR-519b-3p	98.336	NM_020733
HEG1	hsa-miR-519c-3p	98.336	NM_020733
HEG1	hsa-miR-5692a	95.0792	NM_020733
HEG1	hsa-miR-6769b-3p	94.7424	NM_020733
HEG1	hsa-miR-3183	94.7424	NM_020733
HEG1	hsa-miR-4723-3p	94.7424	NM_020733
HEG1	hsa-miR-6501-3p	94.26	NM_020733
HEG1	hsa-miR-186-3p	93.7654	NM_020733
HEG1	hsa-miR-6509-3p	93.7085	NM_020733
HEG1	hsa-miR-106b-5p	93.5882	NM_020733
HEG1	hsa-miR-20a-5p	93.5882	NM_020733
HEG1	hsa-miR-3658	93.3058	NM_020733
HEG1	hsa-miR-17-5p	92.9323	NM_020733
HEG1	hsa-miR-20b-5p	92.9323	NM_020733
HEG1	hsa-miR-519d-3p	92.9323	NM_020733
HEG1	hsa-miR-93-5p	92.9323	NM_020733
HEG1	hsa-miR-526b-3p	92.9121	NM_020733
HEG1	hsa-miR-106a-5p	92.9121	NM_020733
HEG1	hsa-miR-3180-5p	92.6894	NM_020733
HEG1	hsa-miR-149-5p	92.4427	NM_020733
HEG1	hsa-miR-4427	90.3973	NM_020733
HEG1	hsa-miR-6721-5p	89.6639	NM_020733
HEG1	hsa-miR-597-5p	88.1318	NM_020733
HEG1	hsa-miR-181a-2-3p	87.9998	NM_020733
HEG1	hsa-miR-3529-3p	87.5365	NM_020733
HEG1	hsa-miR-4753-3p	87.4771	NM_020733
HEG1	hsa-miR-543	87.4444	NM_020733
HEG1	hsa-miR-139-5p	87.2506	NM_020733
HEG1	hsa-miR-193b-3p	86.3767	NM_020733
HEG1	hsa-miR-193a-3p	86.3767	NM_020733
HEG1	hsa-miR-3666	86.229	NM_020733
HEG1	hsa-miR-301a-3p	86.229	NM_020733
HEG1	hsa-miR-130b-3p	86.229	NM_020733
HEG1	hsa-miR-301b-3p	86.229	NM_020733
HEG1	hsa-miR-4295	86.229	NM_020733
HEG1	hsa-miR-454-3p	86.229	NM_020733
HEG1	hsa-miR-130a-3p	86.229	NM_020733
HEG1	hsa-miR-4775	85.9472	NM_020733
HEG1	hsa-miR-5000-3p	85.3478	NM_020733
HEG1	hsa-miR-4436a	85.2277	NM_020733
HEG1	hsa-miR-27b-3p	85.2101	NM_020733
HEG1	hsa-miR-9985	85.2101	NM_020733
HEG1	hsa-miR-27a-3p	85.2101	NM_020733
HEG1	hsa-miR-590-3p	84.0807	NM_020733
HEG1	hsa-miR-655-3p	83.4447	NM_020733
HEG1	hsa-miR-374c-5p	83.4447	NM_020733
HEG1	hsa-miR-520d-5p	83.2221	NM_020733
HEG1	hsa-miR-524-5p	83.2221	NM_020733
HEG1	hsa-miR-6826-3p	83.0442	NM_020733

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Motifs and transcription factors (TFs) regulating HEG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HEG1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
HEG1	transfac_pro__M04866	HDAC2 (directAnnotation).
HEG1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
HEG1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
HEG1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
HEG1	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
HEG1	taipale_tf_pairs__TEAD4_HOXA13_GGWATGNNNRTAAA_CAP_repr	HOXA13; TEAD4 (directAnnotation).
HEG1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
HEG1	transfac_pro__M06601	ZNF501 (directAnnotation).
HEG1	cisbp__M00161	FOXJ1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."