Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HDLBP

Summary for HDLBP

Gene information	Gene symbol	HDLBP
	Ensembl ID	ENSG00000115677
	Entrez ID	3069
	Gene name	high density lipoprotein binding protein
	Synonyms	HBP\|VGL
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: HDLBP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.403839	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.254709	1.20e-10
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.275619	3.03e-18
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.458514	4.89e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.817002	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	-0.288657	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.258148	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.259217	2.92e-16
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.318694	3.61e-21
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.640739	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.252978	8.37e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.617786	0.00e+00

Top

Expression of HDLBP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to HDLBP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating HDLBP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HDLBP	hsa-miR-4753-5p	93.8225	NM_001243900
HDLBP	hsa-miR-147a	93.7577	NM_001243900
HDLBP	hsa-miR-3119	93.5971	NM_001243900
HDLBP	hsa-miR-340-5p	93.3227	NM_001243900
HDLBP	hsa-miR-6768-5p	92.1957	NM_001243900
HDLBP	hsa-miR-19b-3p	92.045	NM_001243900
HDLBP	hsa-miR-19a-3p	92.045	NM_001243900
HDLBP	hsa-miR-147b-5p	89.6006	NM_001243900
HDLBP	hsa-miR-7-5p	89.5936	NM_001243900
HDLBP	hsa-miR-4458	88.946	NM_001243900
HDLBP	hsa-let-7d-5p	88.946	NM_001243900
HDLBP	hsa-let-7b-5p	88.8575	NM_001243900
HDLBP	hsa-let-7e-5p	88.8575	NM_001243900
HDLBP	hsa-let-7f-5p	88.8575	NM_001243900
HDLBP	hsa-let-7i-5p	88.8575	NM_001243900
HDLBP	hsa-miR-98-5p	88.8575	NM_001243900
HDLBP	hsa-let-7g-5p	88.8575	NM_001243900
HDLBP	hsa-miR-4500	88.8575	NM_001243900
HDLBP	hsa-let-7a-5p	88.8575	NM_001243900
HDLBP	hsa-let-7c-5p	88.8575	NM_001243900
HDLBP	hsa-miR-3688-3p	88.4789	NM_001243900
HDLBP	hsa-miR-4261	86.931	NM_001243900
HDLBP	hsa-miR-3135b	86.7488	NM_001243900
HDLBP	hsa-miR-544b	84.4793	NM_001243900
HDLBP	hsa-miR-4272	83.5629	NM_001320967
HDLBP	hsa-miR-7160-5p	83.4104	NM_001243900
HDLBP	hsa-miR-4255	83.0519	NM_001243900
HDLBP	hsa-miR-5683	82.7133	NM_001320967
HDLBP	hsa-miR-5590-3p	81.8852	NM_001243900
HDLBP	hsa-miR-142-5p	81.8852	NM_001243900
HDLBP	hsa-miR-92a-1-5p	81.753	NM_001243900
HDLBP	hsa-miR-4493	81.2415	NM_001243900
HDLBP	hsa-miR-122b-5p	81.1672	NM_001243900
HDLBP	hsa-miR-448	80.4394	NM_001243900

Page: 1

Top

Motifs and transcription factors (TFs) regulating HDLBP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HDLBP	metacluster_7.13	ZFX (directAnnotation).
HDLBP	cisbp__M01863	ZNF711 (inferredBy_Orthology).
HDLBP	metacluster_151.2	ZNF23 (directAnnotation).
HDLBP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
HDLBP	transfac_pro__M05479	ZNF580 (directAnnotation).
HDLBP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
HDLBP	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
HDLBP	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
HDLBP	transfac_pro__M06071	ZNF814 (directAnnotation).
HDLBP	transfac_pro__M05628	ZNF735 (directAnnotation).
HDLBP	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
HDLBP	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
HDLBP	jaspar__MA0079.5	SP1 (directAnnotation).
HDLBP	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
HDLBP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
HDLBP	transfac_pro__M07397	ZNF148 (directAnnotation).
HDLBP	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
HDLBP	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
HDLBP	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
HDLBP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
HDLBP	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
HDLBP	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
HDLBP	transfac_pro__M01175	ZBTB7B (directAnnotation).
HDLBP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
HDLBP	tfdimers__MD00151	CHURC1 (directAnnotation).
HDLBP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
HDLBP	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
HDLBP	transfac_pro__M01303	SP1 (directAnnotation).
HDLBP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
HDLBP	swissregulon__hs__CHD1	CHD1 (directAnnotation).
HDLBP	transfac_pro__M02090	E2F4 (directAnnotation).
HDLBP	transfac_pro__M01714	KLF15 (directAnnotation).
HDLBP	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
HDLBP	transfac_pro__M02089	E2F3 (directAnnotation).
HDLBP	metacluster_3.14	WT1; WT1 (directAnnotation).
HDLBP	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
HDLBP	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
HDLBP	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
HDLBP	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
HDLBP	cisbp__M07938	E2F1 (directAnnotation).
HDLBP	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
HDLBP	transfac_pro__M07436	WT1 (directAnnotation).
HDLBP	transfac_pro__M02281	SP1 (directAnnotation).
HDLBP	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
HDLBP	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
HDLBP	transfac_pro__M02898	SMAD3 (directAnnotation).
HDLBP	transfac_public__M00491	PATZ1 (directAnnotation).
HDLBP	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
HDLBP	transfac_pro__M06035	ZNF749 (directAnnotation).
HDLBP	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."