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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: HCFC1

Summary for HCFC1

Gene information	Gene symbol	HCFC1
	Ensembl ID	ENSG00000172534
	Entrez ID	3054
	Gene name	host cell factor C1
	Synonyms	CFF\|HCF-1\|HCF1\|HFC1\|MGC70925\|MRX3\|PPP1R89\|VCAF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HCFC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.424822	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.470383	0.00e+00

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Expression of HCFC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HCFC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HCFC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HCFC1	hsa-miR-3529-3p	98.0984	NM_005334
HCFC1	hsa-miR-4728-5p	97.3323	NM_005334
HCFC1	hsa-miR-520b-5p	95.3217	NM_005334
HCFC1	hsa-miR-519a-2-5p	95.3217	NM_005334
HCFC1	hsa-miR-6785-5p	95.2826	NM_005334
HCFC1	hsa-miR-3160-5p	94.4777	NM_005334
HCFC1	hsa-miR-6825-5p	93.9127	NM_005334
HCFC1	hsa-miR-6749-3p	93.6737	NM_005334
HCFC1	hsa-miR-6883-5p	93.4511	NM_005334
HCFC1	hsa-miR-149-3p	93.4511	NM_005334
HCFC1	hsa-miR-6752-3p	90.8819	NM_005334
HCFC1	hsa-miR-8061	89.9065	NM_005334
HCFC1	hsa-miR-4251	89.8451	NM_005334
HCFC1	hsa-miR-196a-1-3p	89.3844	NM_005334
HCFC1	hsa-miR-4760-5p	88.8312	NM_005334
HCFC1	hsa-miR-3613-3p	88.4969	NM_005334
HCFC1	hsa-miR-636	86.9348	NM_005334
HCFC1	hsa-miR-3154	86.0727	NM_005334
HCFC1	hsa-miR-516a-3p	84.7219	NM_005334
HCFC1	hsa-miR-516b-3p	84.7219	NM_005334
HCFC1	hsa-miR-7162-5p	84.7219	NM_005334
HCFC1	hsa-miR-218-5p	84.4317	NM_005334
HCFC1	hsa-miR-4492	83.8838	NM_005334
HCFC1	hsa-miR-6780a-5p	82.4799	NM_005334
HCFC1	hsa-miR-4516	81.455	NM_005334
HCFC1	hsa-miR-6779-5p	80.9749	NM_005334
HCFC1	hsa-miR-937-5p	80.1778	NM_005334

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Motifs and transcription factors (TFs) regulating HCFC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HCFC1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
HCFC1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
HCFC1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
HCFC1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
HCFC1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
HCFC1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
HCFC1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
HCFC1	jaspar__MA0748.2	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
HCFC1	metacluster_34.4	down	Malignant cells	GSE139386	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."