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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HBS1L

Summary for HBS1L

Gene information	Gene symbol	HBS1L
	Ensembl ID	ENSG00000112339
	Entrez ID	10767
	Gene name	HBS1 like translational GTPase
	Synonyms	DKFZp434g247\|EF-1a\|eRF3c\|ERFS\|HBS1\|HSPC276\|KIAA1038
	Gene type	protein_coding
	UniProtAcc	Q9Y450

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Dataset with differentially expressed gene: HBS1L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.417358	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.282473	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.251578	0.00e+00

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Expression of HBS1L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HBS1L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HBS1L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HBS1L	hsa-miR-5696	98.5961	NM_001145158
HBS1L	hsa-miR-4775	98.4069	NM_001145158
HBS1L	hsa-miR-9983-3p	96.6374	NM_001145158
HBS1L	hsa-miR-33b-5p	96.1742	NM_001145158
HBS1L	hsa-miR-33a-5p	96.1742	NM_001145158
HBS1L	hsa-miR-129-5p	95.7053	NM_001145158
HBS1L	hsa-miR-576-5p	93.4593	NM_001145207
HBS1L	hsa-miR-1227-3p	93.2607	NM_001145207
HBS1L	hsa-miR-1252-3p	93.2454	NM_001145158
HBS1L	hsa-miR-4795-3p	92.1978	NM_001145207
HBS1L	hsa-miR-548c-3p	91.8681	NM_001145207
HBS1L	hsa-miR-143-5p	91.6017	NM_001145158
HBS1L	hsa-miR-148b-3p	90.9876	NM_001145207
HBS1L	hsa-miR-148a-3p	90.9876	NM_001145207
HBS1L	hsa-miR-152-3p	90.9876	NM_001145207
HBS1L	hsa-miR-376b-3p	90.7524	NM_001145207
HBS1L	hsa-miR-376a-3p	90.7524	NM_001145207
HBS1L	hsa-miR-586	90.7136	NM_001145158
HBS1L	hsa-miR-95-5p	90.2046	NM_001145158
HBS1L	hsa-miR-335-3p	88.6435	NM_001145207
HBS1L	hsa-miR-3680-3p	88.1036	NM_001145158
HBS1L	hsa-miR-513a-3p	87.9037	NM_001145158
HBS1L	hsa-miR-513c-3p	87.9037	NM_001145158
HBS1L	hsa-miR-7110-3p	87.6788	NM_001145158
HBS1L	hsa-miR-4699-3p	87.6724	NM_001145158
HBS1L	hsa-miR-6844	85.6088	NM_001145158
HBS1L	hsa-miR-590-3p	85.4971	NM_001145158
HBS1L	hsa-miR-371a-5p	84.9715	NM_001145158
HBS1L	hsa-miR-579-3p	84.9334	NM_001145158
HBS1L	hsa-miR-664b-3p	84.9334	NM_001145158
HBS1L	hsa-miR-3606-3p	84.845	NM_001145158
HBS1L	hsa-miR-4528	84.5366	NM_001145207
HBS1L	hsa-miR-190a-3p	84.42	NM_001145207
HBS1L	hsa-miR-651-5p	84.331	NM_001145158
HBS1L	hsa-miR-875-3p	83.9066	NM_001145158
HBS1L	hsa-miR-30d-5p	83.1253	NM_001145207
HBS1L	hsa-miR-30c-5p	83.1253	NM_001145207
HBS1L	hsa-miR-30e-5p	83.1253	NM_001145207
HBS1L	hsa-miR-30b-5p	83.1253	NM_001145207
HBS1L	hsa-miR-30a-5p	83.1253	NM_001145207
HBS1L	hsa-miR-5692a	82.8943	NM_001145158
HBS1L	hsa-miR-4516	82.7085	NM_001145158
HBS1L	hsa-miR-3977	82.5111	NM_001145207
HBS1L	hsa-miR-5692b	82.006	NM_001145158
HBS1L	hsa-miR-5692c	82.006	NM_001145158
HBS1L	hsa-miR-1251-3p	81.442	NM_001145158

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Motifs and transcription factors (TFs) regulating HBS1L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HBS1L	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
HBS1L	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
HBS1L	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
HBS1L	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
HBS1L	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
HBS1L	transfac_pro__M02913	SP140 (inferredBy_Orthology).
HBS1L	jaspar__MA0748.2	YY2 (directAnnotation).
HBS1L	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
HBS1L	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
HBS1L	transfac_pro__M00430	E2F1 (directAnnotation).
HBS1L	hdpi__TP73	TP73 (directAnnotation).
HBS1L	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
HBS1L	hdpi__HIP2	UBE2K (directAnnotation).
HBS1L	hdpi__TIMELESS	TIMELESS (directAnnotation).
HBS1L	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
HBS1L	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
HBS1L	transfac_pro__M00938	E2F1 (directAnnotation).
HBS1L	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
HBS1L	hdpi__RARA	RARA (directAnnotation).
HBS1L	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
HBS1L	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
HBS1L	jaspar__MA1583.1	ZFP57 (directAnnotation).
HBS1L	hdpi__HTATIP2	HTATIP2 (directAnnotation).
HBS1L	jaspar__MA1122.1	TFDP1 (directAnnotation).
HBS1L	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
HBS1L	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
HBS1L	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
HBS1L	metacluster_141.4	GLIS2 (directAnnotation).
HBS1L	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
HBS1L	metacluster_101.3	MYB (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."