Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE164551 | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Immunotherapy | CAR-T | NA | Erythrocytes | 2.44122 | 1.25e-35 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | post | CD8+ T cells | -0.359759 | 5.38e-08 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | post | Erythrocytes | -3.33143 | 2.23e-05 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | post | NK cells | -0.362974 | 1.45e-03 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | pre | Malignant cells | 0.305668 | 6.06e-08 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Erythrocytes | 4.40796 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | B cells | 1.83862 | 1.15e-07 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD4+ T cells | 1.66323 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | NK cells | 1.66961 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
HBG2 | transfac_pro__M06619 | ZNF669 (directAnnotation). |
HBG2 | metacluster_144.1 | ZNF549 (directAnnotation). |
HBG2 | dbtfbs__ZNF157_HEK293_ENCSR564YYW_merged_N1 | ZNF157 (directAnnotation). |
HBG2 | transfac_pro__M06037 | ZNF197 (directAnnotation). |
HBG2 | transfac_pro__M06534 | ZNF563 (directAnnotation). |
HBG2 | metacluster_79.33 | YBX1; YBX1; ZNF264 (directAnnotation). |
HBG2 | transfac_pro__M06770 | ZNF112 (directAnnotation). |
HBG2 | hocomoco__ZKSC3_HUMAN.H11MO.0.D | ZKSCAN3 (directAnnotation). |
HBG2 | transfac_pro__M05683 | ZNF280A (directAnnotation). |
HBG2 | transfac_pro__M06451 | ZNF614 (directAnnotation). |
HBG2 | transfac_pro__M04870 | HDAC2 (directAnnotation). |
HBG2 | taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_2 | SPIB; TEAD4 (directAnnotation). |
HBG2 | taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1 | SPIB; TEAD4 (directAnnotation). |
HBG2 | transfac_pro__M06638 | ZNF570 (directAnnotation). |
HBG2 | taipale_tf_pairs__ETV2_GSC2_RSCGGAANNNNNGGATTA_CAP_repr | ETV2; GSC2 (directAnnotation). |
HBG2 | transfac_pro__M05939 | ZNF471 (directAnnotation). |
HBG2 | transfac_pro__M06665 | ZNF599 (directAnnotation). |
HBG2 | taipale_tf_pairs__GCM1_FOXI1_NNGTMAATANGGGYR_CAP | FOXI1; GCM1 (directAnnotation). |
HBG2 | tfdimers__MD00187 | GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation). |
HBG2 | taipale_tf_pairs__JUN_ATGACGTCAT_HT | JUN (directAnnotation). |
HBG2 | transfac_public__M00041 | ATF2; JUN (directAnnotation). |
HBG2 | jaspar__MA0604.1 | ATF1 (inferredBy_Orthology). |
HBG2 | taipale_tf_pairs__GCM1_FOXI1_RTAAATANGGGNN_CAP_repr | FOXI1; GCM1 (directAnnotation). |
HBG2 | swissregulon__mm__Barhl2 | BARHL2 (inferredBy_Orthology). |
HBG2 | transfac_public__M00039 | CREB1 (directAnnotation). |
HBG2 | taipale_tf_pairs__HOXA4_RTMATTAN_HT | HOXA4 (directAnnotation). |
HBG2 | metacluster_102.1 | NR4A1; ZNF528 (directAnnotation). |
HBG2 | transfac_pro__M06007 | ZNF69 (directAnnotation). |
HBG2 | transfac_pro__M06850 | ZSCAN12 (directAnnotation). |
HBG2 | taipale_tf_pairs__GCM1_FOXO1_GTMAATAAGGGYRN_CAP | FOXO1; GCM1 (directAnnotation). |
HBG2 | transfac_pro__M06754 | ZBTB39 (directAnnotation). |
HBG2 | transfac_pro__M05629 | ZNF44 (directAnnotation). |
HBG2 | tfdimers__MD00510 | HOXA13 (directAnnotation). |
HBG2 | taipale_tf_pairs__GCM2_FOXI1_RTAAATANGGGNN_CAP | FOXI1; GCM2 (directAnnotation). |
HBG2 | kznf__ZNF547_Imbeault2017_OM_MEME | ZNF547 (directAnnotation). |
HBG2 | tfdimers__MD00363 | MEIS1 (directAnnotation). |
HBG2 | transfac_pro__M05767 | ZNF77 (directAnnotation). |
HBG2 | metacluster_15.4 | SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology). |
HBG2 | transfac_pro__M06054 | ZNF99 (directAnnotation). |
HBG2 | taipale_tf_pairs__POU2F1_DLX2_TGMATATKCANNNNTAATKR_CAP_repr | DLX2; POU2F1 (directAnnotation). |
HBG2 | transfac_pro__M00727 | NR5A1 (directAnnotation). |
HBG2 | metacluster_172.28 | ZNF2 (directAnnotation). ZNF2 (inferredBy_Orthology). |
HBG2 | transfac_pro__M05851 | ZNF768 (inferredBy_Orthology). |
HBG2 | transfac_pro__M05692 | ZSCAN21 (inferredBy_Orthology). |
HBG2 | transfac_pro__M04625 | ZBTB16 (directAnnotation). |
HBG2 | metacluster_80.4 | ZIC3 (directAnnotation). |
HBG2 | transfac_pro__M05991 | ZFP64 (directAnnotation). |
HBG2 | metacluster_160.19 | ZNF526 (directAnnotation). ZNF526 (inferredBy_Orthology). |
HBG2 | taipale_tf_pairs__TEAD4_DRGX_RGWATGYTAATKN_CAP | DRGX; TEAD4 (directAnnotation). |
HBG2 | metacluster_174.6 | NFYA; NFYB; NFYB; NFYC (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |