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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene (This gene does not contain this module)
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HBA1

Summary for HBA1

Gene information	Gene symbol	HBA1
	Ensembl ID	ENSG00000206172
	Entrez ID	3039
	Gene name	hemoglobin subunit alpha 1
	Synonyms	HBA-T3
	Gene type	protein_coding
	UniProtAcc	P69905

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Dataset with differentially expressed gene: HBA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	-1.78432	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	0.629085	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	1.00192	4.99e-38
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	-0.608412	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	-1.33294	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	B cells	-0.565111	6.67e-12
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.601847	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	cDCs	-0.553115	4.08e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.411635	2.14e-11
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	Erythrocytes	-1.33687	4.72e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	3.46324	3.31e-09
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	1.48822	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.370983	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	0.618495	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.29769	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	1.56425	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.669489	3.09e-23
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.678401	1.42e-23
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.966296	5.45e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.328425	2.47e-09
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	NK cells	0.305774	1.42e-08
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	CD8+ T cells	0.372802	8.94e-42

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Expression of HBA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HBA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HBA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

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Motifs and transcription factors (TFs) regulating HBA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HBA1	taipale_tf_pairs__TEAD4_FOXI1_GGWATGYGTMAACA_CAP_repr	FOXI1; TEAD4 (directAnnotation).
HBA1	transfac_pro__M06550	ZNF519 (directAnnotation).
HBA1	jaspar__MA1562.1	SOX14 (directAnnotation).
HBA1	taipale_tf_pairs__MEIS1_SOX2_TGACAKNNNAACAATGN_CAP_repr	MEIS1; SOX2 (directAnnotation).
HBA1	hocomoco__HSF1_HUMAN.H11MO.1.A	HSF1 (directAnnotation).
HBA1	transfac_pro__M06543	ZNF418 (directAnnotation).
HBA1	transfac_pro__M05791	ZNF517 (directAnnotation).
HBA1	tfdimers__MD00275	POU2F1; TFAP2A (directAnnotation).
HBA1	metacluster_144.1	ZNF549 (directAnnotation).
HBA1	swissregulon__mm__Stat4	STAT4 (inferredBy_Orthology).
HBA1	transfac_public__M00237	AHR; ARNT (directAnnotation).
HBA1	transfac_pro__M05881	ZNF676 (directAnnotation).
HBA1	taipale_tf_pairs__SOX17_ACCGAACAAT_HT	SOX17 (directAnnotation).
HBA1	transfac_pro__M05545	IKZF4 (inferredBy_Orthology).
HBA1	metacluster_52.10	GTF3C2; ZNF436 (directAnnotation).
HBA1	metacluster_168.11	ZNF771; ZNF771 (directAnnotation).
HBA1	transfac_public__M00291	FOXC1 (directAnnotation).
HBA1	jaspar__MA0033.2	FOXL1 (directAnnotation).
HBA1	transfac_pro__M06688	ZKSCAN7 (directAnnotation).
HBA1	transfac_pro__M05585	HIC2 (directAnnotation).
HBA1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
HBA1	transfac_pro__M06858	ZNF224 (directAnnotation).
HBA1	cisbp__M00838	FOXP1 (directAnnotation).
HBA1	taipale_tf_pairs__ETV2_ONECUT2_RCCGGAANNNNNNRATCRATN_CAP_repr	ETV2; ONECUT2 (directAnnotation).
HBA1	taipale_tf_pairs__ERF_EOMES_TNTCACACCGGAAAT_CAP	EOMES; ERF (directAnnotation).
HBA1	swissregulon__mm__Pbx1	PBX1 (inferredBy_Orthology).
HBA1	transfac_pro__M01968	FOXO1 (directAnnotation).
HBA1	transfac_pro__M06075	ZNF197 (directAnnotation).
HBA1	taipale_tf_pairs__ETV2_TBX21_TMACACMGGAARN_CAP	ETV2; TBX21 (directAnnotation).
HBA1	taipale_tf_pairs__HOXD12_ETV1_RSCGGAAGTAATAAAN_CAP	ETV1; HOXD12 (directAnnotation).
HBA1	transfac_pro__M06047	ZNF726 (directAnnotation).
HBA1	jaspar__MA0031.1	FOXD1 (directAnnotation).
HBA1	metacluster_134.4	AHDC1; ARID5B; FOXA1; FOXA1; FOXA2; FOXA2; FOXA3; FOXA3; FOXJ3; FOXO3; FOXP1; FOXP4 (directAnnotation).
HBA1	taipale__FOXD3_DBD_RTAAAYA	FOXD3 (directAnnotation).
HBA1	taipale_tf_pairs__E2F3_DRGX_SGCGCTAATTKN_CAP_repr	DRGX; E2F3 (directAnnotation).
HBA1	taipale_tf_pairs__SOX6_TBX21_RGGTGTNNNNNNNNNYATTGT_CAP_repr	SOX6; TBX21 (directAnnotation).
HBA1	transfac_pro__M01252	E2F6 (directAnnotation).
HBA1	transfac_pro__M08187	ABL1 (directAnnotation).
HBA1	transfac_pro__M06000	ZNF233 (directAnnotation).
HBA1	cisbp__M00839	FOXP1 (directAnnotation).
HBA1	cisbp__M00161	FOXJ1 (inferredBy_Orthology).
HBA1	metacluster_29.6	ZNF436 (directAnnotation).
HBA1	transfac_pro__M05611	SALL3 (directAnnotation).
HBA1	metacluster_127.2	FOXA1; FOXA2; FOXA3; FOXC1; FOXC1; FOXC2; FOXD1; FOXD1; FOXF2; FOXF2; FOXJ1; FOXK2; FOXK2; FOXO6; FOXP1; FOXP1; FOXP1; FOXP1 (directAnnotation). FOXD2; FOXF1; FOXL3; FOXO1; FOXO3 (inferredBy_Orthology).
HBA1	taipale_tf_pairs__POU2F1_SOX15_NNNGMATAACAAWRRN_CAP_repr	POU2F1; SOX15 (directAnnotation).
HBA1	metacluster_188.1	FOXN2; FOXO4 (directAnnotation). FOXJ1; FOXO3 (inferredBy_Orthology).
HBA1	jaspar__MA1708.1	ETV7 (directAnnotation).
HBA1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
HBA1	transfac_pro__M06230	ZSCAN2 (inferredBy_Orthology).
HBA1	transfac_pro__M06638	ZNF570 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HBA1	"2,6-dicarboxynaphthalene"	DB08262	small molecule
HBA1	"2-[(2-methoxy-5-methylphenoxy)methyl]pyridine"	DB07427	small molecule
HBA1	"2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID"	DB08077	small molecule
HBA1	"4-Carboxycinnamic Acid"	DB02126	small molecule
HBA1	"4-[(5-methoxy-2-methylphenoxy)methyl]pyridine"	DB07428	small molecule
HBA1	"Copper"	DB09130	small molecule
HBA1	"Efaproxiral"	DB08486	small molecule
HBA1	"Ferric derisomaltose"	DB15617	small molecule
HBA1	"Ferric pyrophosphate citrate"	DB13995	small molecule
HBA1	"Ferric pyrophosphate"	DB09147	small molecule
HBA1	"Ferrous ascorbate"	DB14490	small molecule
HBA1	"Ferrous fumarate"	DB14491	small molecule
HBA1	"Ferrous gluconate"	DB14488	small molecule
HBA1	"Ferrous glycine sulfate"	DB14501	small molecule
HBA1	"Ferrous succinate"	DB14489	small molecule
HBA1	"Ferrous sulfate anhydrous"	DB13257	small molecule
HBA1	"Iron Dextran"	DB00893	small molecule
HBA1	"Iron"	DB01592	small molecule
HBA1	"Nitrous acid"	DB09112	small molecule
HBA1	"Pentaerythritol tetranitrate"	DB06154	small molecule
HBA1	"Sebacic acid"	DB07645	small molecule
HBA1	"Sodium ferric gluconate complex"	DB09517	small molecule
HBA1	"Trimesic acid"	DB08632	small molecule
HBA1	"Voxelotor"	DB14975	small molecule
HBA1	"Zinc acetate"	DB14487	small molecule
HBA1	"Zinc chloride"	DB14533	small molecule
HBA1	"Zinc sulfate, unspecified form"	DB14548	small molecule
HBA1	"Zinc"	DB01593	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."