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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HAUS2

Summary for HAUS2

Gene information	Gene symbol	HAUS2
	Ensembl ID	ENSG00000137814
	Entrez ID	55142
	Gene name	HAUS augmin like complex subunit 2
	Synonyms	C15orf25\|CEP27\|FLJ10460\|HsT17025
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HAUS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.27503	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.262722	1.69e-09
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.273765	2.01e-09

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Expression of HAUS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HAUS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HAUS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HAUS2	hsa-miR-548p	97.5274	NM_018097
HAUS2	hsa-miR-8485	96.5056	NM_018097
HAUS2	hsa-miR-4789-3p	93.5499	NM_018097
HAUS2	hsa-miR-10527-5p	93.5012	NM_018097
HAUS2	hsa-miR-548n	92.134	NM_018097
HAUS2	hsa-miR-6742-3p	91.1253	NM_018097
HAUS2	hsa-miR-3941	89.3627	NM_018097
HAUS2	hsa-miR-4503	88.8565	NM_018097
HAUS2	hsa-miR-4776-3p	88.4602	NM_001323629
HAUS2	hsa-miR-6730-5p	88.3679	NM_018097
HAUS2	hsa-miR-5089-5p	87.9887	NM_018097
HAUS2	hsa-miR-4324	87.3033	NM_018097
HAUS2	hsa-miR-4762-3p	87.1054	NM_001323629
HAUS2	hsa-miR-6778-3p	87.0488	NM_018097
HAUS2	hsa-miR-6826-5p	85.2281	NM_001323629
HAUS2	hsa-miR-5699-3p	85.1669	NM_018097
HAUS2	hsa-miR-3662	85.0931	NM_018097
HAUS2	hsa-miR-6504-3p	84.6263	NM_018097
HAUS2	hsa-miR-4421	83.6415	NM_018097
HAUS2	hsa-miR-4666a-5p	82.5896	NM_001323629
HAUS2	hsa-miR-34c-3p	82.3654	NM_001323629
HAUS2	hsa-miR-6831-5p	82.2475	NM_018097
HAUS2	hsa-miR-3927-3p	82.2475	NM_018097
HAUS2	hsa-miR-758-3p	81.2424	NM_018097
HAUS2	hsa-miR-570-3p	81.1584	NM_018097
HAUS2	hsa-miR-548t-5p	80.9623	NM_018097
HAUS2	hsa-miR-548az-5p	80.9623	NM_018097
HAUS2	hsa-miR-581	80.9415	NM_018097
HAUS2	hsa-miR-548e-5p	80.6534	NM_001323629
HAUS2	hsa-miR-331-5p	80.1519	NM_001323629

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Motifs and transcription factors (TFs) regulating HAUS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HAUS2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
HAUS2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
HAUS2	cisbp__M08198	ELF1 (directAnnotation).
HAUS2	jaspar__MA1708.1	ETV7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."