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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HAS3

Summary for HAS3

Gene information	Gene symbol	HAS3
	Ensembl ID	ENSG00000103044
	Entrez ID	3038
	Gene name	hyaluronan synthase 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O00219

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Dataset with differentially expressed gene: HAS3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.18564	3.43e-04

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Expression of HAS3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HAS3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HAS3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HAS3	hsa-miR-29c-3p	98.6683	NM_001199280
HAS3	hsa-miR-29a-3p	98.6683	NM_001199280
HAS3	hsa-miR-29b-3p	98.6683	NM_001199280
HAS3	hsa-miR-498-3p	93.488	NM_001199280
HAS3	hsa-miR-6835-3p	90.8343	NM_001199280
HAS3	hsa-miR-519b-3p	90.4537	NM_005329
HAS3	hsa-miR-519c-3p	90.4537	NM_005329
HAS3	hsa-miR-519a-3p	90.4537	NM_005329
HAS3	hsa-miR-143-5p	90.3308	NM_005329
HAS3	hsa-miR-1285-5p	89.3568	NM_005329
HAS3	hsa-miR-1297	89.3217	NM_001199280
HAS3	hsa-miR-4667-3p	87.8636	NM_001199280
HAS3	hsa-miR-6766-3p	87.7097	NM_001199280
HAS3	hsa-miR-219a-5p	87.7097	NM_001199280
HAS3	hsa-miR-4782-3p	87.7097	NM_001199280
HAS3	hsa-miR-26b-5p	86.6969	NM_001199280
HAS3	hsa-miR-26a-5p	86.6969	NM_001199280
HAS3	hsa-miR-2355-3p	86.1381	NM_001199280
HAS3	hsa-miR-4776-5p	86.006	NM_005329
HAS3	hsa-miR-4465	85.4935	NM_001199280
HAS3	hsa-miR-3915	83.5446	NM_005329
HAS3	hsa-miR-4308	83.4537	NM_005329
HAS3	hsa-miR-4325	82.9853	NM_001199280
HAS3	hsa-miR-10a-5p	81.9827	NM_001199280
HAS3	hsa-miR-10b-5p	81.9827	NM_001199280
HAS3	hsa-miR-3677-3p	80.5232	NM_005329

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Motifs and transcription factors (TFs) regulating HAS3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HAS3	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
HAS3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
HAS3	transfac_pro__M07387	ZBTB7A (directAnnotation).
HAS3	transfac_pro__M07436	WT1 (directAnnotation).
HAS3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
HAS3	transfac_pro__M00716	ZBTB14 (directAnnotation).
HAS3	transfac_pro__M03876	ZBTB33 (directAnnotation).
HAS3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
HAS3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
HAS3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."