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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HAS2

Summary for HAS2

Gene information	Gene symbol	HAS2
	Ensembl ID	ENSG00000170961
	Entrez ID	3037
	Gene name	hyaluronan synthase 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q92819

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Dataset with differentially expressed gene: HAS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.317657	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.671158	0.00e+00

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Expression of HAS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HAS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HAS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HAS2	hsa-miR-96-5p	99.8669	NM_005328
HAS2	hsa-miR-182-5p	99.84	NM_005328
HAS2	hsa-miR-12133	99.8108	NM_005328
HAS2	hsa-miR-1271-5p	99.8038	NM_005328
HAS2	hsa-miR-7150	99.6173	NM_005328
HAS2	hsa-miR-202-3p	97.1705	NM_005328
HAS2	hsa-miR-1294	96.5065	NM_005328
HAS2	hsa-miR-9986	96.5065	NM_005328
HAS2	hsa-miR-548at-5p	96.4796	NM_005328
HAS2	hsa-miR-6875-3p	95.9934	NM_005328
HAS2	hsa-miR-106b-5p	94.7237	NM_005328
HAS2	hsa-miR-20b-5p	94.7237	NM_005328
HAS2	hsa-miR-519d-3p	94.7237	NM_005328
HAS2	hsa-miR-106a-5p	94.7237	NM_005328
HAS2	hsa-miR-526b-3p	94.7237	NM_005328
HAS2	hsa-miR-93-5p	94.7237	NM_005328
HAS2	hsa-miR-17-5p	94.7237	NM_005328
HAS2	hsa-miR-20a-5p	94.7237	NM_005328
HAS2	hsa-miR-211-5p	93.9677	NM_005328
HAS2	hsa-miR-204-5p	93.9677	NM_005328
HAS2	hsa-miR-3064-3p	93.905	NM_005328
HAS2	hsa-miR-6721-5p	92.8794	NM_005328
HAS2	hsa-miR-6832-3p	92.3385	NM_005328
HAS2	hsa-miR-4659a-3p	92.2922	NM_005328
HAS2	hsa-miR-4659b-3p	92.2922	NM_005328
HAS2	hsa-let-7i-5p	91.604	NM_005328
HAS2	hsa-let-7b-5p	91.604	NM_005328
HAS2	hsa-let-7f-5p	91.604	NM_005328
HAS2	hsa-let-7c-5p	91.604	NM_005328
HAS2	hsa-let-7a-5p	91.604	NM_005328
HAS2	hsa-miR-98-5p	91.604	NM_005328
HAS2	hsa-miR-4500	91.604	NM_005328
HAS2	hsa-let-7g-5p	91.604	NM_005328
HAS2	hsa-let-7e-5p	91.604	NM_005328
HAS2	hsa-miR-4458	91.0924	NM_005328
HAS2	hsa-let-7d-5p	91.0924	NM_005328
HAS2	hsa-miR-23a-3p	90.2188	NM_005328
HAS2	hsa-miR-23b-3p	90.2188	NM_005328
HAS2	hsa-miR-23c	90.2188	NM_005328
HAS2	hsa-miR-519a-3p	88.9982	NM_005328
HAS2	hsa-miR-519b-3p	88.9982	NM_005328
HAS2	hsa-miR-519c-3p	88.9982	NM_005328
HAS2	hsa-miR-511-5p	88.9457	NM_005328
HAS2	hsa-miR-595	88.1444	NM_005328
HAS2	hsa-miR-5006-3p	88.1436	NM_005328
HAS2	hsa-miR-4755-5p	88.1436	NM_005328
HAS2	hsa-miR-4511	87.7719	NM_005328
HAS2	hsa-miR-3667-3p	87.4548	NM_005328
HAS2	hsa-miR-579-3p	86.9762	NM_005328
HAS2	hsa-miR-664b-3p	86.9762	NM_005328

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Motifs and transcription factors (TFs) regulating HAS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HAS2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
HAS2	cisbp__M00808	MYPOP (inferredBy_Orthology).
HAS2	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
HAS2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
HAS2	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
HAS2	metacluster_111.5	E4F1; E4F1 (directAnnotation).
HAS2	transfac_pro__M04748	GABPA (directAnnotation).
HAS2	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
HAS2	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."