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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HAPLN1

Summary for HAPLN1

Gene information	Gene symbol	HAPLN1
	Ensembl ID	ENSG00000145681
	Entrez ID	1404
	Gene name	hyaluronan and proteoglycan link protein 1
	Synonyms	CRTL1
	Gene type	protein_coding
	UniProtAcc	P10915

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Dataset with differentially expressed gene: HAPLN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.978317	0.00e+00

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Expression of HAPLN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HAPLN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HAPLN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HAPLN1	hsa-miR-3148	99.2551	NM_001884
HAPLN1	hsa-miR-1277-5p	98.9044	NM_001884
HAPLN1	hsa-miR-199a-5p	97.7802	NM_001884
HAPLN1	hsa-miR-199b-5p	97.7802	NM_001884
HAPLN1	hsa-miR-5692c	97.5931	NM_001884
HAPLN1	hsa-miR-5692b	97.5931	NM_001884
HAPLN1	hsa-miR-636	97.4353	NM_001884
HAPLN1	hsa-miR-4495	96.9742	NM_001884
HAPLN1	hsa-let-7c-3p	95.9966	NM_001884
HAPLN1	hsa-miR-4775	95.4786	NM_001884
HAPLN1	hsa-miR-888-5p	94.9113	NM_001884
HAPLN1	hsa-miR-6740-5p	94.7402	NM_001884
HAPLN1	hsa-miR-6730-5p	94.2976	NM_001884
HAPLN1	hsa-miR-607	94.0182	NM_001884
HAPLN1	hsa-miR-4279	93.8506	NM_001884
HAPLN1	hsa-miR-6893-5p	93.8355	NM_001884
HAPLN1	hsa-miR-940	93.8355	NM_001884
HAPLN1	hsa-miR-6808-5p	93.8355	NM_001884
HAPLN1	hsa-miR-218-5p	93.4946	NM_001884
HAPLN1	hsa-miR-3143	93.1788	NM_001884
HAPLN1	hsa-miR-600	93.0992	NM_001884
HAPLN1	hsa-miR-9983-3p	92.9914	NM_001884
HAPLN1	hsa-miR-374a-5p	92.7591	NM_001884
HAPLN1	hsa-miR-4743-3p	92.5908	NM_001884
HAPLN1	hsa-miR-7976	92.4973	NM_001884
HAPLN1	hsa-miR-27b-3p	92.3625	NM_001884
HAPLN1	hsa-miR-27a-3p	92.3625	NM_001884
HAPLN1	hsa-miR-9985	92.3625	NM_001884
HAPLN1	hsa-miR-4319	91.4056	NM_001884
HAPLN1	hsa-miR-5006-3p	91.3034	NM_001884
HAPLN1	hsa-miR-5001-3p	91.1108	NM_001884
HAPLN1	hsa-miR-2116-5p	90.7592	NM_001884
HAPLN1	hsa-miR-374b-5p	90.5363	NM_001884
HAPLN1	hsa-miR-129-5p	90.4791	NM_001884
HAPLN1	hsa-miR-6728-5p	90.2556	NM_001884
HAPLN1	hsa-miR-890	90.0239	NM_001884
HAPLN1	hsa-miR-7154-5p	89.4238	NM_001884
HAPLN1	hsa-miR-3977	89.4183	NM_001884
HAPLN1	hsa-miR-548at-5p	89.3978	NM_001884
HAPLN1	hsa-miR-211-5p	89.2273	NM_001884
HAPLN1	hsa-miR-204-5p	89.2273	NM_001884
HAPLN1	hsa-miR-125b-5p	89.1169	NM_001884
HAPLN1	hsa-miR-125a-5p	89.1169	NM_001884
HAPLN1	hsa-miR-9-3p	88.8214	NM_001884
HAPLN1	hsa-miR-548ar-3p	88.784	NM_001884
HAPLN1	hsa-miR-2113	88.5435	NM_001884
HAPLN1	hsa-miR-4755-5p	88.4285	NM_001884
HAPLN1	hsa-miR-5089-5p	88.3686	NM_001884
HAPLN1	hsa-miR-340-5p	87.6991	NM_001884
HAPLN1	hsa-miR-4427	87.6341	NM_001884

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Motifs and transcription factors (TFs) regulating HAPLN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HAPLN1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
HAPLN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
HAPLN1	transfac_pro__M07397	ZNF148 (directAnnotation).
HAPLN1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
HAPLN1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
HAPLN1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
HAPLN1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
HAPLN1	metacluster_7.13	ZFX (directAnnotation).
HAPLN1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
HAPLN1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
HAPLN1	transfac_pro__M01175	ZBTB7B (directAnnotation).
HAPLN1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
HAPLN1	tfdimers__MD00151	CHURC1 (directAnnotation).
HAPLN1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
HAPLN1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
HAPLN1	transfac_pro__M01303	SP1 (directAnnotation).
HAPLN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
HAPLN1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
HAPLN1	transfac_pro__M02090	E2F4 (directAnnotation).
HAPLN1	transfac_pro__M01714	KLF15 (directAnnotation).
HAPLN1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
HAPLN1	jaspar__MA1122.1	TFDP1 (directAnnotation).
HAPLN1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
HAPLN1	transfac_pro__M02089	E2F3 (directAnnotation).
HAPLN1	transfac_pro__M12604	ZNF444 (directAnnotation).
HAPLN1	metacluster_3.14	WT1; WT1 (directAnnotation).
HAPLN1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
HAPLN1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
HAPLN1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
HAPLN1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
HAPLN1	cisbp__M07938	E2F1 (directAnnotation).
HAPLN1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
HAPLN1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
HAPLN1	transfac_pro__M07436	WT1 (directAnnotation).
HAPLN1	transfac_pro__M02281	SP1 (directAnnotation).
HAPLN1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
HAPLN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
HAPLN1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
HAPLN1	transfac_pro__M02898	SMAD3 (directAnnotation).
HAPLN1	transfac_public__M00491	PATZ1 (directAnnotation).
HAPLN1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
HAPLN1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HAPLN1	"Hyaluronic acid"	DB08818	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."