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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HADHB

Summary for HADHB

Gene information	Gene symbol	HADHB
	Ensembl ID	ENSG00000138029
	Entrez ID	3032
	Gene name	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
	Synonyms	MTPB
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HADHB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.340114	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.31784	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.465502	1.58e-28

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Expression of HADHB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HADHB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HADHB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HADHB	hsa-miR-33b-5p	96.8918	NM_000183
HADHB	hsa-miR-33a-5p	96.8918	NM_000183
HADHB	hsa-miR-587	96.3296	NM_000183
HADHB	hsa-miR-5087	95.5975	NM_000183
HADHB	hsa-miR-4493	94.6407	NM_000183
HADHB	hsa-miR-1197	94.13	NM_000183
HADHB	hsa-miR-450b-5p	94.0171	NM_000183
HADHB	hsa-miR-3622a-5p	93.7542	NM_000183
HADHB	hsa-miR-4423-3p	93.389	NM_000183
HADHB	hsa-miR-345-3p	91.148	NM_000183
HADHB	hsa-miR-5582-5p	91.0554	NM_000183
HADHB	hsa-miR-4317	90.9009	NM_000183
HADHB	hsa-miR-4717-5p	89.8084	NM_000183
HADHB	hsa-miR-520d-5p	89.7745	NM_000183
HADHB	hsa-miR-524-5p	89.7745	NM_000183
HADHB	hsa-miR-6809-5p	89.3512	NM_000183
HADHB	hsa-miR-4760-5p	87.5455	NM_000183
HADHB	hsa-miR-8061	85.8358	NM_000183
HADHB	hsa-miR-4680-3p	85.469	NM_000183
HADHB	hsa-miR-670-5p	85.0166	NM_000183
HADHB	hsa-miR-5700	84.9225	NM_000183
HADHB	hsa-miR-1256	82.807	NM_000183
HADHB	hsa-miR-4319	81.9504	NM_000183

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Motifs and transcription factors (TFs) regulating HADHB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HADHB	transfac_pro__M04918	EGR1 (directAnnotation).
HADHB	hdpi__FLI1	FLI1 (directAnnotation).
HADHB	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
HADHB	metacluster_172.6	CHD2; E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."