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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HACD3

Summary for HACD3

Gene information	Gene symbol	HACD3
	Ensembl ID	ENSG00000074696
	Entrez ID	51495
	Gene name	3-hydroxyacyl-CoA dehydratase 3
	Synonyms	B-ind1\|HSPC121\|PTPLAD1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HACD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.588879	2.57e-02
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.347059	1.90e-21
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.266394	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.256997	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.338858	3.27e-24

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Expression of HACD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HACD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HACD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HACD3	hsa-miR-6867-5p	99.9836	NM_016395
HACD3	hsa-miR-206	99.6941	NM_016395
HACD3	hsa-miR-1-3p	99.6299	NM_016395
HACD3	hsa-miR-613	99.5551	NM_016395
HACD3	hsa-miR-4307	99.1132	NM_016395
HACD3	hsa-miR-4801	98.383	NM_016395
HACD3	hsa-miR-4731-3p	97.6656	NM_016395
HACD3	hsa-miR-6507-5p	96.4899	NM_016395
HACD3	hsa-miR-216a-5p	95.5419	NM_016395
HACD3	hsa-miR-1324	94.213	NM_016395
HACD3	hsa-miR-135b-3p	93.8813	NM_016395
HACD3	hsa-miR-891a-5p	93.24	NM_016395
HACD3	hsa-miR-5704	93.2044	NM_016395
HACD3	hsa-miR-33a-3p	91.3755	NM_016395
HACD3	hsa-miR-135a-2-3p	90.5964	NM_016395
HACD3	hsa-miR-4722-5p	89.6914	NM_016395
HACD3	hsa-miR-508-3p	88.8314	NM_016395
HACD3	hsa-miR-509-5p	88.8205	NM_016395
HACD3	hsa-miR-509-3-5p	88.8205	NM_016395
HACD3	hsa-miR-890	88.5368	NM_016395
HACD3	hsa-miR-125b-2-3p	88.243	NM_016395
HACD3	hsa-miR-548az-3p	87.9608	NM_016395
HACD3	hsa-miR-4418	87.8355	NM_016395
HACD3	hsa-miR-299-5p	87.2959	NM_016395
HACD3	hsa-miR-548ar-3p	86.5605	NM_016395
HACD3	hsa-miR-4700-5p	86.2875	NM_016395
HACD3	hsa-miR-8089	86.2875	NM_016395
HACD3	hsa-miR-4667-5p	86.2875	NM_016395
HACD3	hsa-miR-302c-5p	85.4928	NM_016395
HACD3	hsa-miR-3143	84.5687	NM_016395
HACD3	hsa-miR-6835-3p	84.5375	NM_016395
HACD3	hsa-miR-635	83.8195	NM_016395
HACD3	hsa-miR-5680	83.0452	NM_016395
HACD3	hsa-miR-548e-3p	82.8651	NM_016395
HACD3	hsa-miR-548a-3p	82.8651	NM_016395
HACD3	hsa-miR-548f-3p	82.8651	NM_016395
HACD3	hsa-miR-548bc	82.8651	NM_016395
HACD3	hsa-miR-4437	82.8453	NM_016395
HACD3	hsa-miR-3120-3p	82.2881	NM_016395
HACD3	hsa-miR-4799-5p	81.4415	NM_016395
HACD3	hsa-miR-10526-3p	80.6998	NM_016395

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Motifs and transcription factors (TFs) regulating HACD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HACD3	transfac_public__M00024	E2F1 (directAnnotation).
HACD3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
HACD3	transfac_pro__M04950	EGR1 (directAnnotation).
HACD3	transfac_pro__M01182	HINFP (directAnnotation).
HACD3	transfac_pro__M00652	NRF1 (directAnnotation).
HACD3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
HACD3	metacluster_7.13	ZFX (directAnnotation).
HACD3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
HACD3	cisbp__M00968	MTF2 (directAnnotation).
HACD3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
HACD3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
HACD3	cisbp__M00788	ZFY (inferredBy_Orthology).
HACD3	hdpi__ZNF304	ZNF304 (directAnnotation).
HACD3	transfac_pro__M01199	TRIM28 (directAnnotation).
HACD3	transfac_pro__M03806	ZBTB7C (directAnnotation).
HACD3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
HACD3	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
HACD3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
HACD3	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
HACD3	jaspar__MA0748.2	YY2 (directAnnotation).
HACD3	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
HACD3	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
HACD3	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."