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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: H3-3B

Summary for H3-3B

Gene information	Gene symbol	H3-3B
	Ensembl ID	ENSG00000132475
	Entrez ID	3021
	Gene name	H3.3 histone B
	Synonyms	H3.3B\|H3F3B
	Gene type	protein_coding
	UniProtAcc	P84243

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Dataset with differentially expressed gene: H3-3B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Progenitors	0.596022	1.52e-03
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.350703	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.776547	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-1.45485	0.00e+00

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Expression of H3-3B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to H3-3B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating H3-3B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
H3-3B	hsa-miR-128-3p	95.1904	NM_005324
H3-3B	hsa-miR-216a-3p	95.1904	NM_005324
H3-3B	hsa-miR-4793-5p	94.7787	NM_005324
H3-3B	hsa-miR-338-5p	94.4663	NM_005324
H3-3B	hsa-miR-22-3p	94.3187	NM_005324
H3-3B	hsa-miR-3681-3p	94.0253	NM_005324
H3-3B	hsa-miR-4536-5p	91.2187	NM_005324
H3-3B	hsa-miR-340-5p	90.6491	NM_005324
H3-3B	hsa-miR-938	88.1324	NM_005324
H3-3B	hsa-miR-361-3p	87.9514	NM_005324
H3-3B	hsa-miR-3163	86.9559	NM_005324
H3-3B	hsa-miR-129-2-3p	86.9523	NM_005324
H3-3B	hsa-miR-129-1-3p	86.9523	NM_005324
H3-3B	hsa-miR-224-5p	86.5738	NM_005324
H3-3B	hsa-miR-4719	86.0748	NM_005324
H3-3B	hsa-miR-1233-3p	84.9171	NM_005324
H3-3B	hsa-miR-4496	83.6468	NM_005324
H3-3B	hsa-miR-1257	83.6392	NM_005324
H3-3B	hsa-miR-630	81.904	NM_005324
H3-3B	hsa-miR-138-5p	80.7863	NM_005324
H3-3B	hsa-miR-668-3p	80.5882	NM_005324

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Motifs and transcription factors (TFs) regulating H3-3B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."