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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: H2AZ1

Summary for H2AZ1

Gene information	Gene symbol	H2AZ1
	Ensembl ID	ENSG00000164032
	Entrez ID	3015
	Gene name	H2A.Z variant histone 1
	Synonyms	H2A.Z\|H2AFZ\|H2AZ
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: H2AZ1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.378684	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.302768	2.21e-41
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	1.60886	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.259259	0.00e+00

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Expression of H2AZ1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to H2AZ1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating H2AZ1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
H2AZ1	hsa-miR-200a-3p	96.4423	NM_002106
H2AZ1	hsa-miR-141-3p	96.4423	NM_002106
H2AZ1	hsa-miR-548an	96.0919	NM_002106
H2AZ1	hsa-miR-6759-3p	95.7781	NM_002106
H2AZ1	hsa-miR-6838-3p	94.91	NM_002106
H2AZ1	hsa-miR-4324	94.1178	NM_002106
H2AZ1	hsa-miR-7112-3p	92.7809	NM_002106
H2AZ1	hsa-miR-298	91.5068	NM_002106
H2AZ1	hsa-miR-4786-3p	90.5441	NM_002106
H2AZ1	hsa-miR-7843-3p	90.507	NM_002106
H2AZ1	hsa-miR-5002-5p	90.057	NM_002106
H2AZ1	hsa-miR-1200	89.5491	NM_002106
H2AZ1	hsa-miR-544b	88.7068	NM_002106
H2AZ1	hsa-miR-4668-3p	87.5324	NM_002106
H2AZ1	hsa-miR-4756-3p	86.7681	NM_002106
H2AZ1	hsa-miR-4328	86.654	NM_002106
H2AZ1	hsa-miR-3978	84.6102	NM_002106
H2AZ1	hsa-miR-8068	84.4503	NM_002106
H2AZ1	hsa-miR-6513-5p	83.5189	NM_002106
H2AZ1	hsa-miR-92a-1-5p	83.5158	NM_002106
H2AZ1	hsa-miR-212-3p	82.8236	NM_002106
H2AZ1	hsa-miR-132-3p	82.8236	NM_002106
H2AZ1	hsa-miR-4432	82.5748	NM_002106
H2AZ1	hsa-miR-499a-5p	82.1817	NM_002106
H2AZ1	hsa-miR-1468-3p	81.664	NM_002106
H2AZ1	hsa-miR-5007-5p	80.7223	NM_002106

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Motifs and transcription factors (TFs) regulating H2AZ1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."