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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GZMK

Summary for GZMK

Gene information	Gene symbol	GZMK
	Ensembl ID	ENSG00000113088
	Entrez ID	3003
	Gene name	granzyme K
	Synonyms	PRSS\|TRYP2
	Gene type	protein_coding
	UniProtAcc	P49863

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Dataset with differentially expressed gene: GZMK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.697963	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	-0.337629	1.53e-29
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.321311	6.46e-36
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.254858	2.34e-34
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	-0.531266	2.68e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.660208	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	-0.516324	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.72093	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.851637	1.20e-12
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.762676	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.886944	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.294116	1.29e-08
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	0.430681	1.08e-18
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	CD8+ T cells	-0.290481	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.682572	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.429542	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	NK cells	-0.881576	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-1.01416	1.31e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.875706	9.94e-15
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	0.815574	1.09e-25
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.777348	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	CD8+ T cells	0.382775	3.19e-28
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	NK cells	0.321295	1.09e-02

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Expression of GZMK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GZMK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GZMK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GZMK	hsa-miR-4650-3p	92.8882	NM_002104
GZMK	hsa-miR-145-3p	87.5559	NM_002104
GZMK	hsa-miR-4799-5p	87.1189	NM_002104
GZMK	hsa-miR-6740-3p	83.7051	NM_002104

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Motifs and transcription factors (TFs) regulating GZMK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GZMK	homer__ATTAACACCT_Eomes	EOMES (directAnnotation).
GZMK	transfac_pro__M06784	ZNF780B (directAnnotation).
GZMK	transfac_pro__M06162	ZNF93 (directAnnotation).
GZMK	transfac_pro__M05544	BCL11A (directAnnotation).
GZMK	tfdimers__MD00425	ELF5; SMAD4 (directAnnotation).
GZMK	kznf__ZNF45_Imbeault2017_OM_RCADE	ZNF45 (directAnnotation).
GZMK	swissregulon__hs__OVOL1	OVOL1 (directAnnotation).
GZMK	taipale_tf_pairs__HOXD12_ETV4_RSCGGAAGTAATAAAN_CAP	ETV4; HOXD12 (directAnnotation).
GZMK	metacluster_14.4	BHLHE40 (inferredBy_Orthology).
GZMK	metacluster_14.6	ARNTL; BHLHE40; BHLHE40; CLOCK (directAnnotation). ARNTL; BHLHE41 (inferredBy_Orthology).
GZMK	taipale_cyt_meth__FOXO3_NTCCCCACACN_eDBD	FOXO3 (directAnnotation).
GZMK	jaspar__MA1560.1	SOHLH2 (directAnnotation).
GZMK	transfac_pro__M05545	IKZF4 (inferredBy_Orthology).
GZMK	taipale_tf_pairs__MYCL2_SCACGTGS_HT	MYCLP1 (directAnnotation).
GZMK	transfac_pro__M05709	ZNF136 (directAnnotation).
GZMK	metacluster_14.3	BHLHE40 (inferredBy_Orthology).
GZMK	transfac_public__M00291	FOXC1 (directAnnotation).
GZMK	jaspar__MA1106.1	HIF1A (directAnnotation).
GZMK	metacluster_14.17	ARNT2; ARNTL; BHLHE40 (directAnnotation). BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL (inferredBy_Orthology).
GZMK	transfac_pro__M06342	ZNF329 (inferredBy_Orthology).
GZMK	transfac_pro__M06404	ZNF497 (directAnnotation).
GZMK	taipale_tf_pairs__HOXD12_ELK3_RSCGGAAGTAATAAAN_CAP	ELK3; HOXD12 (directAnnotation).
GZMK	transfac_pro__M06896	ZFP3 (inferredBy_Orthology).
GZMK	taipale_tf_pairs__HOXD12_ETV4_RSCGGAAGTCGTAAAN_CAP	ETV4; HOXD12 (directAnnotation).
GZMK	taipale_tf_pairs__HOXD12_ETV1_RSCGGAAGTNGTAAAN_CAP	ETV1; HOXD12 (directAnnotation).
GZMK	transfac_pro__M01252	E2F6 (directAnnotation).
GZMK	transfac_pro__M06108	ZNF43 (directAnnotation).
GZMK	hocomoco__BPTF_HUMAN.H11MO.0.D	BPTF (directAnnotation).
GZMK	transfac_pro__M03849	SOX4 (directAnnotation).
GZMK	metacluster_119.1	ZNF677 (directAnnotation).
GZMK	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
GZMK	tfdimers__MD00075	FOXO4; NANOG (directAnnotation).
GZMK	metacluster_97.2	GTF3A (inferredBy_Orthology).
GZMK	metacluster_130.15	ARID5B; ARID5B; BPTF (directAnnotation).
GZMK	metacluster_147.6	MGA; TBX1; TBX1; TBX1; TBX15; TBX19; TBX19; TBX20; TBX20; TBX21; TBX6; TBXT; TBXT; TBXT; TBXT; TBXT (directAnnotation). TBX18; TBX6 (inferredBy_Orthology).
GZMK	taipale_tf_pairs__ETV2_GSC2_RSCGGAANNNNNGGATTA_CAP_repr	ETV2; GSC2 (directAnnotation).
GZMK	transfac_pro__M05829	ZNF627 (directAnnotation).
GZMK	transfac_pro__M05760	ZNF648 (directAnnotation).
GZMK	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
GZMK	transfac_pro__M05706	ZNF20 (directAnnotation).
GZMK	metacluster_154.1	PAX4 (directAnnotation). PAX4 (inferredBy_Orthology).
GZMK	jaspar__MA1633.2	BACH1 (directAnnotation).
GZMK	metacluster_100.2	ZNF440 (directAnnotation).
GZMK	transfac_pro__M06332	ZNF585A (directAnnotation).
GZMK	tfdimers__MD00404	FOXA1; FOXA2; FOXA3; FOXP3 (directAnnotation).
GZMK	metacluster_178.20	ZKSCAN1 (directAnnotation). ZKSCAN1 (inferredBy_Orthology).
GZMK	transfac_pro__M05646	ZNF879 (directAnnotation).
GZMK	transfac_pro__M06542	ZNF502 (directAnnotation).
GZMK	metacluster_172.3	SMAD7 (directAnnotation). SMAD7 (inferredBy_Orthology).
GZMK	transfac_pro__M06265	ZNF791 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."