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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GTF3C4

Summary for GTF3C4

Gene information	Gene symbol	GTF3C4
	Ensembl ID	ENSG00000125484
	Entrez ID	9329
	Gene name	general transcription factor IIIC subunit 4
	Synonyms	KAT12\|TFIIIC90
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GTF3C4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.28102	6.39e-16

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Expression of GTF3C4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GTF3C4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GTF3C4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GTF3C4	hsa-miR-548ap-3p	98.1666	NM_012204
GTF3C4	hsa-miR-548t-3p	98.1666	NM_012204
GTF3C4	hsa-miR-548aa	98.1666	NM_012204
GTF3C4	hsa-miR-1299	96.5532	NM_012204
GTF3C4	hsa-miR-4306	96.0262	NM_012204
GTF3C4	hsa-miR-518c-5p	95.7616	NM_012204
GTF3C4	hsa-miR-4652-3p	95.0312	NM_012204
GTF3C4	hsa-miR-4326	93.9795	NM_012204
GTF3C4	hsa-miR-6889-3p	92.7314	NM_012204
GTF3C4	hsa-miR-570-3p	92.6897	NM_012204
GTF3C4	hsa-miR-7151-3p	92.5963	NM_012204
GTF3C4	hsa-miR-6529-3p	92.1083	NM_012204
GTF3C4	hsa-miR-4644	90.0836	NM_012204
GTF3C4	hsa-miR-185-5p	90.0836	NM_012204
GTF3C4	hsa-miR-514b-3p	89.5794	NM_012204
GTF3C4	hsa-miR-514a-3p	89.5794	NM_012204
GTF3C4	hsa-miR-642b-3p	88.5807	NM_012204
GTF3C4	hsa-miR-642a-3p	88.5807	NM_012204
GTF3C4	hsa-miR-4528	88.5451	NM_012204
GTF3C4	hsa-miR-4666a-3p	87.9317	NM_012204
GTF3C4	hsa-miR-1827	87.8868	NM_012204
GTF3C4	hsa-miR-6124	87.8639	NM_012204
GTF3C4	hsa-miR-664a-3p	87.5666	NM_012204
GTF3C4	hsa-miR-6885-3p	87.442	NM_012204
GTF3C4	hsa-miR-517-5p	87.3188	NM_012204
GTF3C4	hsa-miR-1285-5p	86.7902	NM_012204
GTF3C4	hsa-miR-3678-3p	86.0478	NM_012204
GTF3C4	hsa-miR-3613-3p	85.6487	NM_012204
GTF3C4	hsa-miR-548aj-3p	85.1426	NM_012204
GTF3C4	hsa-miR-548x-3p	85.1426	NM_012204
GTF3C4	hsa-let-7e-3p	85.0379	NM_012204
GTF3C4	hsa-miR-5197-5p	84.8297	NM_012204
GTF3C4	hsa-miR-373-5p	84.3782	NM_012204
GTF3C4	hsa-miR-371b-5p	84.3782	NM_012204
GTF3C4	hsa-miR-616-5p	84.3782	NM_012204
GTF3C4	hsa-miR-548d-3p	84.2227	NM_012204
GTF3C4	hsa-miR-6715a-3p	83.8349	NM_012204
GTF3C4	hsa-miR-548aq-3p	83.2135	NM_012204
GTF3C4	hsa-miR-548ae-3p	83.2135	NM_012204
GTF3C4	hsa-miR-548j-3p	83.2135	NM_012204
GTF3C4	hsa-miR-429	82.4449	NM_012204
GTF3C4	hsa-miR-200b-3p	82.4449	NM_012204
GTF3C4	hsa-miR-200c-3p	82.4449	NM_012204
GTF3C4	hsa-miR-4261	81.7816	NM_012204
GTF3C4	hsa-miR-548am-3p	81.5634	NM_012204
GTF3C4	hsa-miR-548ah-3p	81.5634	NM_012204
GTF3C4	hsa-miR-548z	81.3137	NM_012204
GTF3C4	hsa-miR-548ac	81.3137	NM_012204
GTF3C4	hsa-miR-548h-3p	81.3137	NM_012204
GTF3C4	hsa-miR-6824-3p	81.3072	NM_012204

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Motifs and transcription factors (TFs) regulating GTF3C4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GTF3C4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."