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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GSTM3

Summary for GSTM3

Gene information	Gene symbol	GSTM3
	Ensembl ID	ENSG00000134202
	Entrez ID	2947
	Gene name	glutathione S-transferase mu 3
	Synonyms	GST5
	Gene type	protein_coding
	UniProtAcc	P21266

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Dataset with differentially expressed gene: GSTM3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.407274	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.667636	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.357896	5.40e-28
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Erythrocytes	-0.434486	6.41e-03

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Expression of GSTM3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GSTM3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GSTM3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GSTM3	hsa-miR-302e	87.9201	NM_000849
GSTM3	hsa-miR-4775	87.0799	NM_000849
GSTM3	hsa-miR-4755-5p	84.4224	NM_000849
GSTM3	hsa-miR-204-5p	83.8417	NM_000849
GSTM3	hsa-miR-211-5p	83.8417	NM_000849
GSTM3	hsa-miR-4445-5p	81.2649	NM_000849
GSTM3	hsa-miR-302a-3p	81.2542	NM_000849
GSTM3	hsa-miR-302b-3p	81.2542	NM_000849
GSTM3	hsa-miR-302d-3p	81.2542	NM_000849
GSTM3	hsa-miR-302c-3p	81.2542	NM_000849
GSTM3	hsa-miR-186-5p	80.5057	NM_000849
GSTM3	hsa-miR-500b-3p	80.2811	NM_000849
GSTM3	hsa-miR-5006-3p	80.0976	NM_000849

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Motifs and transcription factors (TFs) regulating GSTM3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GSTM3	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
GSTM3	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
GSTM3	transfac_pro__M06104	ZNF16 (directAnnotation).
GSTM3	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNYMATTA_CAP_repr	DLX3; TFAP2C (directAnnotation).
GSTM3	jaspar__MA1708.1	ETV7 (directAnnotation).
GSTM3	taipale_tf_pairs__ERF_MAX_RSCGGAANCACGTGN_CAP_repr	ERF; MAX (directAnnotation).
GSTM3	kznf__ZNF200_Najafabadi2015_ChIP-seq	ZNF200 (directAnnotation).
GSTM3	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
GSTM3	transfac_pro__M04950	EGR1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GSTM3	"Glutathione"	DB00143	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."