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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GSTK1

Summary for GSTK1

Gene information	Gene symbol	GSTK1
	Ensembl ID	ENSG00000197448
	Entrez ID	373156
	Gene name	glutathione S-transferase kappa 1
	Synonyms	GST13
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GSTK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.304564	1.76e-38
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.297229	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.306963	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.353964	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.265274	1.11e-17
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.302927	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	-0.430793	7.73e-05
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.508774	6.31e-04
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.352916	0.00e+00

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Expression of GSTK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GSTK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GSTK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GSTK1	hsa-miR-4316	96.5453	NM_001143679
GSTK1	hsa-let-7d-3p	80.5589	NM_001143679
GSTK1	hsa-miR-4283	80.4644	NM_001143679

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Motifs and transcription factors (TFs) regulating GSTK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GSTK1	hdpi__ETV4	ETV4 (directAnnotation).
GSTK1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
GSTK1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
GSTK1	transfac_pro__M05894	ZNF565 (directAnnotation).
GSTK1	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
GSTK1	transfac_pro__M06605	ZNF681 (directAnnotation).
GSTK1	hdpi__RAB18	RAB18 (directAnnotation).
GSTK1	transfac_pro__M06251	ZSCAN2 (inferredBy_Orthology).
GSTK1	dbtfbs__SETDB1_HEK293_ENCSR348AGV_merged_N1	SETDB1 (directAnnotation).
GSTK1	metacluster_35.3	EHF; EHF; EHF; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF2; ELF2; ELF2; ELF2; ELF2; ELF3; ELF3; ELF3; ELF3; ELF4; ELF4; ELF4; ELF4; ELF5; ELF5; ELF5; ELF5; ELK3; ERG; ETV2; ETV2; ETV5; FLI1; FLI1; ZNF639 (directAnnotation). EHF; ELF4; ETS1; FLI1; SPDEF (inferredBy_Orthology).
GSTK1	transfac_pro__M06130	ZNF254 (directAnnotation).
GSTK1	transfac_pro__M06686	PRDM9 (directAnnotation).
GSTK1	transfac_pro__M06273	ZNF766 (directAnnotation).
GSTK1	tfdimers__MD00399	ELF5; NFATC3 (directAnnotation).
GSTK1	transfac_pro__M06141	ZNF708 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GSTK1	"GLUTATHIONE SULFINATE"	DB04700	small molecule
GSTK1	"Glutathione"	DB00143	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."