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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GRSF1

Summary for GRSF1

Gene information	Gene symbol	GRSF1
	Ensembl ID	ENSG00000132463
	Entrez ID	2926
	Gene name	G-rich RNA sequence binding factor 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q12849

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Dataset with differentially expressed gene: GRSF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.266786	5.65e-08
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.554568	3.75e-39
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.398881	2.11e-28
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.286939	6.83e-08
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.404826	1.73e-22
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.262203	5.15e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.418713	0.00e+00

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Expression of GRSF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GRSF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GRSF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GRSF1	hsa-miR-19a-3p	98.6208	NM_001098477
GRSF1	hsa-miR-19b-3p	98.6208	NM_001098477
GRSF1	hsa-miR-3613-3p	96.9262	NM_001098477
GRSF1	hsa-miR-4799-5p	92.6449	NM_001098477
GRSF1	hsa-miR-513a-5p	92.126	NM_001098477
GRSF1	hsa-miR-8077	90.7955	NM_001098477
GRSF1	hsa-miR-4742-5p	90.6507	NM_001098477
GRSF1	hsa-miR-4786-3p	90.5838	NM_001098477
GRSF1	hsa-miR-4487	89.3526	NM_001098477
GRSF1	hsa-miR-4728-5p	87.0179	NM_001098477
GRSF1	hsa-miR-4422	86.5231	NM_001098477
GRSF1	hsa-miR-133a-5p	86.0261	NM_001098477
GRSF1	hsa-miR-373-5p	85.4634	NM_001098477
GRSF1	hsa-miR-616-5p	85.4634	NM_001098477
GRSF1	hsa-miR-371b-5p	85.4634	NM_001098477
GRSF1	hsa-miR-6785-5p	85.0816	NM_001098477
GRSF1	hsa-miR-149-3p	84.7313	NM_001098477
GRSF1	hsa-miR-3194-5p	84.637	NM_001098477
GRSF1	hsa-miR-3620-3p	84.0373	NM_001098477
GRSF1	hsa-miR-6883-5p	83.5481	NM_001098477
GRSF1	hsa-miR-1297	83.3038	NM_001098477
GRSF1	hsa-miR-377-3p	82.9572	NM_001098477
GRSF1	hsa-miR-9-5p	82.7957	NM_001098477
GRSF1	hsa-miR-3646	82.2774	NM_001098477
GRSF1	hsa-miR-1236-3p	81.9615	NM_001098477
GRSF1	hsa-miR-4738-3p	81.4679	NM_001098477
GRSF1	hsa-miR-4469	81.3767	NM_001098477
GRSF1	hsa-miR-6858-5p	81.2738	NM_001098477
GRSF1	hsa-miR-4689	81.2697	NM_001098477
GRSF1	hsa-miR-4786-5p	80.2507	NM_001098477

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Motifs and transcription factors (TFs) regulating GRSF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GRSF1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
GRSF1	transfac_pro__M05479	ZNF580 (directAnnotation).
GRSF1	jaspar__MA0079.5	SP1 (directAnnotation).
GRSF1	hdpi__TP73	TP73 (directAnnotation).
GRSF1	transfac_pro__M04950	EGR1 (directAnnotation).
GRSF1	metacluster_55.5	ZNF541 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."