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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GREM1

Summary for GREM1

Gene information	Gene symbol	GREM1
	Ensembl ID	ENSG00000276886
	Entrez ID	26585
	Gene name	gremlin 1, DAN family BMP antagonist
	Synonyms	CKTSF1B1\|CRAC1\|DAND2\|DRM\|gremlin\|HMPS
	Gene type	protein_coding
	UniProtAcc	O60565

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Dataset with differentially expressed gene: GREM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.638996	0.00e+00

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Expression of GREM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GREM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GREM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GREM1	hsa-miR-4480	96.4927	NM_013372
GREM1	hsa-miR-6819-5p	94.8209	NM_001191322
GREM1	hsa-miR-6737-5p	94.8209	NM_001191322
GREM1	hsa-miR-6812-5p	93.1046	NM_001191322
GREM1	hsa-miR-329-5p	92.3713	NM_001191322
GREM1	hsa-miR-4464	91.4504	NM_001191322
GREM1	hsa-miR-4748	91.4504	NM_001191322
GREM1	hsa-miR-216a-3p	90.9674	NM_013372
GREM1	hsa-miR-128-3p	90.9674	NM_013372
GREM1	hsa-miR-4503	90.2133	NM_013372
GREM1	hsa-miR-3922-3p	89.7471	NM_001191322
GREM1	hsa-miR-4753-3p	88.9194	NM_013372
GREM1	hsa-miR-3176	88.3419	NM_001191322
GREM1	hsa-miR-3681-3p	88.1451	NM_013372
GREM1	hsa-miR-5190	87.8048	NM_013372
GREM1	hsa-miR-4477b	87.201	NM_001191322
GREM1	hsa-miR-12120	86.9808	NM_001191322
GREM1	hsa-miR-4757-5p	86.0933	NM_001191322
GREM1	hsa-miR-6744-3p	86.0933	NM_001191322
GREM1	hsa-miR-4786-3p	85.8484	NM_001191322
GREM1	hsa-miR-4775	82.9612	NM_013372
GREM1	hsa-miR-6792-5p	82.559	NM_001191322
GREM1	hsa-miR-7843-3p	82.1279	NM_001191322
GREM1	hsa-miR-4270	81.1473	NM_001191322
GREM1	hsa-miR-4279	80.9916	NM_013372
GREM1	hsa-miR-6754-5p	80.9024	NM_001191322
GREM1	hsa-miR-4441	80.8765	NM_001191322

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Motifs and transcription factors (TFs) regulating GREM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GREM1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
GREM1	transfac_pro__M04950	EGR1 (directAnnotation).
GREM1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
GREM1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
GREM1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
GREM1	transfac_pro__M00652	NRF1 (directAnnotation).
GREM1	transfac_pro__M04866	HDAC2 (directAnnotation).
GREM1	jaspar__MA1122.1	TFDP1 (directAnnotation).
GREM1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
GREM1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."