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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GRB2

Summary for GRB2

Gene information	Gene symbol	GRB2
	Ensembl ID	ENSG00000177885
	Entrez ID	2885
	Gene name	growth factor receptor bound protein 2
	Synonyms	NCKAP2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GRB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.789769	3.84e-07
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.29966	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.274506	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.294906	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.357283	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.282198	3.35e-11
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	cDCs	-0.319166	6.70e-03
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.282881	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.312856	1.15e-06
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.361871	8.04e-07
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.383201	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.347332	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.309899	2.26e-43
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.406417	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.265281	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.37	1.60e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.250019	4.53e-07
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.294288	7.46e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.496591	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.308013	7.47e-26
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.361157	0.00e+00

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Expression of GRB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GRB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
GRB2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating GRB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GRB2	hsa-miR-4789-5p	97.202	NM_002086
GRB2	hsa-miR-3941	95.667	NM_002086
GRB2	hsa-miR-153-3p	95.2735	NM_002086
GRB2	hsa-miR-4795-3p	94.7738	NM_002086
GRB2	hsa-miR-141-3p	93.8227	NM_002086
GRB2	hsa-miR-200a-3p	93.8227	NM_002086
GRB2	hsa-miR-3680-3p	92.3965	NM_002086
GRB2	hsa-miR-8485	92.1841	NM_002086
GRB2	hsa-miR-4672	90.6581	NM_002086
GRB2	hsa-miR-182-5p	90.4023	NM_002086
GRB2	hsa-miR-96-5p	90.4023	NM_002086
GRB2	hsa-miR-12123	89.8874	NM_002086
GRB2	hsa-miR-4708-3p	89.6342	NM_002086
GRB2	hsa-miR-513a-5p	89.4921	NM_002086
GRB2	hsa-miR-12133	88.9556	NM_002086
GRB2	hsa-miR-9985	88.6785	NM_002086
GRB2	hsa-miR-27b-3p	88.6785	NM_002086
GRB2	hsa-miR-27a-3p	88.6785	NM_002086
GRB2	hsa-miR-1271-5p	88.2861	NM_002086
GRB2	hsa-miR-4520-3p	87.7776	NM_002086
GRB2	hsa-miR-448	87.3368	NM_002086
GRB2	hsa-miR-6745	86.8948	NM_002086
GRB2	hsa-miR-506-3p	86.1228	NM_002086
GRB2	hsa-miR-124-3p	86.1228	NM_002086
GRB2	hsa-miR-548an	85.8061	NM_002086
GRB2	hsa-miR-362-3p	85.0656	NM_002086
GRB2	hsa-miR-329-3p	85.0656	NM_002086
GRB2	hsa-miR-603	85.0656	NM_002086
GRB2	hsa-miR-126-5p	84.3286	NM_002086
GRB2	hsa-miR-363-5p	84.316	NM_002086
GRB2	hsa-miR-4644	83.483	NM_002086
GRB2	hsa-miR-5000-5p	82.5373	NM_002086
GRB2	hsa-miR-4424	81.4769	NM_002086
GRB2	hsa-miR-5685	80.7664	NM_002086
GRB2	hsa-miR-4690-3p	80.7664	NM_002086
GRB2	hsa-miR-578	80.471	NM_002086

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Motifs and transcription factors (TFs) regulating GRB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GRB2	metacluster_7.13	ZFX (directAnnotation).
GRB2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
GRB2	metacluster_151.2	ZNF23 (directAnnotation).
GRB2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GRB2	hdpi__ETV4	ETV4 (directAnnotation).
GRB2	transfac_pro__M05628	ZNF735 (directAnnotation).
GRB2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
GRB2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GRB2	jaspar__MA0079.5	SP1 (directAnnotation).
GRB2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
GRB2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
GRB2	metacluster_3.14	WT1; WT1 (directAnnotation).
GRB2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
GRB2	metacluster_135.11	NR2C2 (directAnnotation).
GRB2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GRB2	cisbp__M00968	MTF2 (directAnnotation).
GRB2	cisbp__M00341	PAX6 (directAnnotation).
GRB2	metacluster_198.3	ZFP64 (directAnnotation).
GRB2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GRB2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
GRB2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GRB2	cisbp__M00788	ZFY (inferredBy_Orthology).
GRB2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
GRB2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
GRB2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GRB2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GRB2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GRB2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GRB2	transfac_pro__M03806	ZBTB7C (directAnnotation).
GRB2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GRB2	hdpi__TP73	TP73 (directAnnotation).
GRB2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
GRB2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
GRB2	jaspar__MA1708.1	ETV7 (directAnnotation).
GRB2	transfac_pro__M00492	STAT1 (directAnnotation).
GRB2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
GRB2	hdpi__HIP2	UBE2K (directAnnotation).
GRB2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
GRB2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
GRB2	transfac_pro__M02898	SMAD3 (directAnnotation).
GRB2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
GRB2	transfac_pro__M04893	TAF1 (directAnnotation).
GRB2	cisbp__M00249	WT1 (directAnnotation).
GRB2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
GRB2	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
GRB2	transfac_pro__M00938	E2F1 (directAnnotation).
GRB2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
GRB2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
GRB2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
GRB2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GRB2	"4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5	DB03276	small molecule
GRB2	"Pegademase"	DB00061	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."